ENTRAINMENT OF ANTICIPATORY ACTIVITY TO VARIOUS DURATIONS OF FOOD ACCESS
ENTRAINMENT OF ANTICIPATORY ACTIVITY TO VARIOUS DURATIONS OF FOOD ACCESS
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DOI：
10.1016/0031-9384(89)90359-4
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发表时间：
1989-10-01
影响因子：
2.9
通讯作者：
BECKER, G
中科院分区：
文献类型：
--
作者：
STEPHAN, FK;BECKER, G
损毁视交叉上核(SCN)的大鼠和正常大鼠维持限食喂养，进食时间为4~12小时。所有SCN损伤的大鼠在所有食物获取时间内至少表现出一些预期活动(AA)。当食物获取时间延长到12小时时，AA的数量减少，在预计只有10小时获取时间的一组中，AA的数量最低。Aa(夹带相角)的开始似乎对食物可获得的时间比它的终止更敏感。大多数保持在恒定光照下的完整大鼠在4到10小时之间的食物获取时间显示出一些AA。在大多数情况下，自由奔跑节律的周期随着穿过食物通道而增加，随着实验的进行，所有大鼠的自由奔跑节律越来越被打乱。在某些情况下，自由奔跑的节奏似乎迫使AA摆脱了夹带。这些结果表明，再生障碍性贫血发生在只对大鼠能量平衡造成轻微缺陷的条件下。此外，它们还提供了两个独立的昼夜节律起搏系统之间相互作用的额外证据。
Rats with lesions of the suprachiasmatic nuclei (SCN) and intact rats were maintained on restricted feeding with the duration of food access ranging from 4 to 12 hr. All rats with SCN lesions displayed at least some anticipatory activity (AA) at all food access duration. The amount of AA diminished when food access was extended to 12 hr and was lowest in a group that was expected only to a 10-hr access period. The onset of AA (phase angle of entrainment) appeared to be more sensitive to the time of food availability than to its termination. Most intact rats maintained in constant light displayed some AA at food access durations betwen 4 and 10 hr. In most cases the period of the free running rhythm increased as it crossed food access and the free running rhythm became increasingly disrupted as the experiment progressed in all rats. In some cases the free running rhythm appeared to force AA out of entrainment. These results demonstrate that AA occurs in conditions that impose only minor deficits on the energy balance of rats. Furthermore, they provide additional evidence of interactions between two separate circadian pacemaking systems.