HYPOTHALAMIC SELF-STIMULATION IN 3 INBRED STRAINS OF MICE
HYPOTHALAMIC SELF-STIMULATION IN 3 INBRED STRAINS OF MICE
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DOI：
10.1016/0006-8993(74)90485-5
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发表时间：
1974-01-01
期刊：
影响因子：
2.9
通讯作者：
CARDO, B
中科院分区：
文献类型：
--
作者：
CAZALA, P;CAZALS, Y;CARDO, B
将3个近交系雄性小鼠(DBA/2 Orl、BALB/c Orl和C57BL/6 Orl)在下丘脑植入双极电极，并进行自我刺激试验。3个品系表现不同：BALB/c小鼠得分高于DBA/2小鼠，DBA/2小鼠本身也高于C57BL/6小鼠。这些品系在癫痫发作的频率、阈值和暂停其自我刺激行为的性质上也不同。此外，对每种品系的背侧和腹侧下丘脑植入进行了比较。在3个品系中，背侧植入的自我刺激得分高于腹侧。另一方面，腹侧埋植更容易发生癫痫发作。
Male mice from 3 inbred strains (DBA/2 Orl, BALB/c Orl and C57 BL/6 Orl) were implanted with a bipolar electrode in the hypothalamus and tested for self-stimulation. The 3 strains differed in performances: the BALB/c mice showed higher scores than the DBA/2 mice which themselves showed higher rates than the C57 BL/6 mice. These strains also differed in frequency, threshold and the nature of seizures suspending their self-stimulation behavior.Moreover, for each strain, a comparison between dorsal and ventral hypothalamus implantation was made. In the 3 strains dorsal implantation gave higher self-stimulation scores than ventral. On the other hand the seizures occured more frequently with ventral implantations.