A quantitative trait locus genome scan for porcine muscle fiber traits reveals overdominance and epistasis
A quantitative trait locus genome scan for porcine muscle fiber traits reveals overdominance and epistasis
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DOI：
10.2527/jas.2008-1034
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发表时间：
2008-12-01
影响因子：
3.3
通讯作者：
Perez-Enciso, M.
中科院分区：
文献类型：
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作者：
Estelle, J.;Gil, F.;Perez-Enciso, M.
肌肉组织化学特性是决定肉质的决定性因素。不同肌肉纤维类型的相对百分比和直径会影响肉类的关键方面，如颜色、嫩度和最终的pH值。然而，尽管与此相关，关于肌肉纤维遗传结构的信息仍然很少，因为组织化学肌肉表征是一项繁重的任务。在这里，我们报道了利用139个标记对伊比利亚猪和长白猪F-2杂交的160头动物的肌肉纤维性状进行了完整的QTL扫描。我们确定了分布在15条猪染色体(SSC1、2、3、4、6、7、8、9、10、11、12、13、14、15和X)上的20个基因组区域，它们具有直接和(或)上位性效应。上位性频繁，一些交互作用极显著。10号和11号染色体似乎表现为枢纽；它们包含2个单独的QTL，但也有6个上位区。许多个体QTL效应具有隐蔽的等位基因，与表型纯品种差异的效应相反。这里发现的许多QTL与以前文献中关于这些性状的报道相吻合，并且与潜在的候选基因和先前报道的肉质QTL存在重叠。
Muscle histochemical characteristics are decisive determinants of meat quality. The relative percentage and diameters of the different muscular fiber types influence crucial aspects of meat such as color, tenderness, and ultimate pH. Despite its relevance, however, the information on muscle fiber genetic architecture is scant, because histochemical muscle characterization is a laborious task. Here we report a complete QTL scan of muscle fiber traits in 160 animals from a F-2 cross between Iberian and Landrace pigs using 139 markers. We identified 20 genome regions distributed along 15 porcine chromosomes (SSC1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and X) with direct and( or) epistatic effects. Epistasis was frequent and some interactions were highly significant. Chromosomes 10 and 11 seemed to behave as hubs; they harbored 2 individual QTL, but also 6 epistatic regions. Numerous individual QTL effects had cryptic alleles, with opposite effects to phenotypic pure breed differences. Many of the QTL identified here coincided with previous reports for these traits in the literature, and there was overlapping with potential candidate genes and previously reported meat quality QTL.