The Children of Atomic Bomb Survivors: A Genetic Study
The Children of Atomic Bomb Survivors: A Genetic Study
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原子弹爆炸幸存者的孩子：基因研究
DOI：
10.1001/jama.1992.03490050109039
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
C. Heath
中科院分区：
文献类型：
--
作者：
C. Heath
对日本原子弹爆炸幸存者的健康跟踪研究至今已进行了近50年，这是对日本和美国自第二次世界大战以来持续进行科学合作的一个显著贡献。从一开始，基因研究就受到特别关注。在广岛和长崎进行的第一项以人口为基础的工作涉及一项大型临床流行病学调查，其中确定了所有晚期妊娠结局（1948年至1953年五年期间近77 000例妊娠），然后对与父母暴露于原子弹照射有关的临床研究。没有发现差异（在出生缺陷，死产等的频率），从而减轻了公众对原子辐射可能产生畸形儿童流行病的直接担忧。此后，F1代的鉴定几乎持续了暴露种群的整个生殖生命期（1945年至1985年）。这项工作与对受辐射父母的所有后代及其子女的临床检查相结合
Health follow-up studies of Japanese atomic bomb survivors have now been in progress for nearly 50 years, a remarkable tribute to sustained scientific cooperation between Japan and the United States since World War II. From the beginning, genetic research has received particular attention. The first population-based work in Hiroshima and Nagasaki involved a large clinical-epidemiological investigation in which all late-term pregnancy outcomes were identified (nearly 77 000 pregnancies over a five-year period, 1948 through 1953) and then studied clinically in relation to parental exposure to bomb irradiation. No differences were found (in frequencies of birth defects, stillbirths, etc), thus allaying the immediate public concern that atomic radiation might spawn an epidemic of malformed children. Identification of the Fl generation continued thereafter for nearly the entire reproductive life of the exposed population (1945 through 1985). That work was coupled with clinical examination of all offspring of exposed parents, together with children