The epidemiology of bone cancer in 0-39 year olds in northern England, 1981-2002
The epidemiology of bone cancer in 0-39 year olds in northern England, 1981-2002
复制标题
DOI：
10.1186/1471-2407-10-357
复制
发表时间：
2010-07-06
期刊：
影响因子：
3.8
通讯作者：
McNally, Richard J. Q.
中科院分区：
文献类型：
--
作者：
Eyre, Rachel;Feltbower, Richard G.;McNally, Richard J. Q.
背景：关于骨癌的最新流行病学数据很少。本研究的目的是描述 1981 - 2002 年间诊断的骨癌的发病率和生存模式。方法：使用泊松和考克斯回归分析 0 - 39 岁的病例（236 例骨肉瘤、166 例尤文肉瘤和 73 例软骨肉瘤）。结果：骨肉瘤的发病率（每年每百万人）在 0 - 39 岁时为 2.5。 14 年； 15 - 29 岁为 4.5，30 - 39 岁为 1.0。同样，尤文肉瘤的发病率为 2.2； 2.9； 0.4，软骨肉瘤的发生率为 0.1； 1.2；分别为1.8。骨肉瘤的发病率以年均2.5%的速度增加（95% CI 0.4 - 4.7；P = 0.02），但尤文肉瘤或软骨肉瘤的发病率没有变化。尽管 15 - 39 岁患者 (n = 93) 的总生存率比 0 - 14 岁患者 (n = 73; HR = 1.46; 95% CI 0.98 - 2.17；P=0.06）。骨肉瘤生存率无显着改善（每年 HR = 0.98；95% CI 0.95 - 1.01；P = 0.18）。结论：15 - 39 岁尤文肉瘤患者生存率较差以及未能显着提高骨肉瘤患者生存率的原因需要进一步调查。
Background: There is a paucity of recent epidemiological data on bone cancers. The aim of this study was to describe incidence and survival patterns for bone cancers diagnosed during 1981 - 2002.Methods: Cases aged 0 - 39 years (236 osteosarcomas, 166 Ewing sarcomas and 73 chondrosarcomas) were analysed using Poisson and Cox regressions.Results: Incidence rates (per million persons per year) for osteosarcoma were 2.5 at age 0 - 14 years; 4.5 at age 15 - 29 years and 1.0 at age 30 - 39 years. Similarly, for Ewing sarcoma the incidence rates were 2.2; 2.9; 0.4 and for chondrosarcoma rates were 0.1; 1.2; 1.8 respectively. Incidence of osteosarcoma increased at an average annual rate of 2.5% (95% CI 0.4 - 4.7; P = 0.02), but there was no change in incidence of Ewing sarcoma or chondrosarcoma. There was a marginally statistically significant improvement in survival for Ewing sarcoma (hazard ratio (HR) per annum = 0.97; 95% CI 0.94 - 1.00; P = 0.06), although patients aged 15 - 39 years (n = 93) had worse overall survival than those aged 0 - 14 (n = 73; HR = 1.46; 95% CI 0.98 - 2.17; P = 0.06). There was no significant improvement in osteosarcoma survival (HR per annum = 0.98; 95% CI 0.95 - 1.01; P = 0.18).Conclusions: Reasons for poorer survival in Ewing sarcoma patients aged 15 - 39 years and failure to significantly improve survival for osteosarcoma patients requires further investigation.