Measurement of Retinal Vascular Caliber From Optical Coherence Tomography Phase Images
Measurement of Retinal Vascular Caliber From Optical Coherence Tomography Phase Images
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DOI：
10.1167/iovs.15-18476
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Schmetterer, Leopold
中科院分区：
文献类型：
--
作者：
Fondi, Klemens;Aschinger, Gerold C.;Schmetterer, Leopold
目的.比较从相敏光学相干断层扫描（OCT）图像中提取的视网膜血管口径与从视网膜血管分析仪（RVA）获得的血管口径。使用了先前发表的13例呼吸室内空气的健康受试者（n = 214支血管）和7例呼吸100%氧气的受试者（n = 101支血管）的研究数据。通过三个独立的分级器沿光轴沿着垂直测量OCT相位图像的血管口径。对RVA眼底图像的数据进行放大校正，以获得绝对值。在常氧条件下，从OCT图像获得的平均血管直径低于RVA图像（83.8 +/- 28.2 μ m vs 86.6 +/- 28.0 μ m，P < 0.001）。在100%氧呼吸期间观察到相同的现象（OCT：81.0 +/- 22.4 μ m，RVA：85.5 +/- 26.0 μ m; P = 0.001）。虽然两种方法之间的一致性通常较高，但单个血管的差异可能高达40%。这些差异既不依赖于绝对血管尺寸，也不优选在特定受试者中发现。OCT评价者之间的观察者间差异远低于技术之间的差异。从OCT相位图像中提取血管口径可能是克服与眼底成像相关联的一些问题的有吸引力的方法。两种方法之间血管口径差异的来源仍有待研究。此外，在全身性或眼部疾病的风险分层中，基于OCT的血管口径测量是否上级基于眼底相机的成像仍不清楚。
PURPOSE. To compare retinal vessel calibers extracted from phase-sensitive optical coherence tomography (OCT) images with vessel calibers as obtained from the Retinal Vessel Analyzer (RVA).METHODS. Data from previously published studies in 13 healthy subjects breathing room air (n = 214 vessels) and 7 subjects breathing 100% oxygen (n = 101 vessels) were used. Vessel calibers from OCT phase images were measured vertically along the optical axis by three independent graders. The data from RVA fundus images were corrected for magnification to obtain absolute values.RESULTS. The average vessel diameter as obtained from OCT images during normoxia was lower than from RVA images (83.8 +/- 28.2 mu m versus 86.6 +/- 28.0 mu m, P < 0.001). The same phenomenon was observed during 100% oxygen breathing (OCT: 81.0 +/- 22.4 mu m, RVA: 85.5 +/- 26.0 mu m; P = 0.001). Although the agreement between the two methods was generally high, the difference in individual vessels could be as high as 40%. These differences were neither dependent on absolute vessel size nor preferably found in specific subjects. Interobserver differences between OCT evaluators were much lower than differences between the techniques.CONCLUSIONS. Extracting vessel calibers from OCT phase images may be an attractive approach to overcome some of the problems associated with fundus imaging. The source of differences in vessel caliber between the two methods remains to be investigated. In addition, it remains unclear whether OCT-based vessel caliber measurement is superior to fundus camera-based imaging in risk stratification for systemic or ocular disease.