Diffusion tensor imaging of basal ganglia and thalamus in amyotrophic lateral sclerosis.
Diffusion tensor imaging of basal ganglia and thalamus in amyotrophic lateral sclerosis.
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DOI：
10.1111/j.1552-6569.2011.00679.x
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Govind V
中科院分区：
文献类型：
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作者：
Sharma KR;Sheriff S;Maudsley A;Govind V
目的应用扩散张量成像（DTI）技术评价肌萎缩侧索硬化（ALS）患者基底节和丘脑受累情况。14名确诊ALS患者和12名年龄匹配的对照者在3 T扫描仪上进行了全脑DTI。从感兴趣区域（ROI）的双侧基底神经节和丘脑获得平均扩散率（MD）和各向异性分数（FA）。ALS患者基底节和丘脑的MD显著高于对照组（p < 0.02）。相应地，与对照组相比，除了尾状核（p =0.04）和壳核（p = 0.06）外，患者的FA在这些结构中显著降低（p <0.02）。基底神经节的DTI测量值与手指敲击、足部敲击和唇舌运动速率之间存在轻度到强相关性（r：0.3 - 0.7）。基底神经节和丘脑中MD的增加以及苍白球和丘脑中FA的减少指示这些结构中的神经元损失或功能障碍。
To assess the involvement of basal ganglia and thalamus in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI) method. Fourteen definite-ALS patients and 12 age-matched controls underwent whole brain DTI on a 3T scanner. Mean-diffusivity (MD) and fractional anisotropy (FA) were obtained bilaterally from the basal ganglia and thalamus in the regions-of-interest (ROI). The MD was significantly higher (p < 0.02) in basal ganglia and thalamus in patients with ALS compared with controls. Correspondingly, the FA was significantly lower (p < 0.02) in these structures, except in caudate (p =0.04) and putamen (p = 0.06) in patients compared with controls. There were mild to strong correlations (r: 0.3 – 0.7) between the DTI measures of basal ganglia and finger–tap, foot-tap, and lip-and-tongue-movement-rate. The increased MD in basal ganglia and thalamus, and decreased FA in globus pallidus and thalamus are indicative of neuronal loss or dysfunction in these structures.