Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis
Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis
复制标题
DOI：
10.1007/s00198-012-2161-0
复制
发表时间：
2012-12-01
影响因子：
4
通讯作者：
Houard, X.
中科院分区：
文献类型：
--
作者：
Mahjoub, M.;Berenbaum, F.;Houard, X.
骨关节炎是一种全关节疾病，其特征在于与软骨下骨硬化相关的软骨消失、骨赘形成和滑膜轻度炎症。虽然所有这些事件都已被独立研究，但这些不同关节组织之间应该存在功能性相互作用，特别是在软骨下骨和软骨之间。此外，最近的研究表明，软骨和软骨下骨作为一个单一的功能单位。本综述强调了这一新颖的概念。
Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions between these different joint tissues should exist, especially between subchondral bone and cartilage. Moreover, recent studies show that cartilage and subchondral bone act as a single functional unit. This review highlights this novel concept.