REMOVING THE HEART FROM THE BRAIN - COMPENSATION FOR THE PULSE ARTIFACT IN THE PHOTON MIGRATION SIGNAL
REMOVING THE HEART FROM THE BRAIN - COMPENSATION FOR THE PULSE ARTIFACT IN THE PHOTON MIGRATION SIGNAL
复制标题
DOI：
10.1111/j.1469-8986.1995.tb02958.x
复制
发表时间：
1995-05-01
期刊：
影响因子：
3.7
通讯作者：
CORBALLIS, PM
中科院分区：
文献类型：
--
作者：
GRATTON, G;CORBALLIS, PM
各种因素，包括血红蛋白浓度的变化，决定了活组织对近红外光的透明度的变化。因此，光学措施已被提出作为一种非侵入性的方法，用于调查区域的大脑活动的变化。然而，穿过头部区域的近红外光的量也受到心动周期（脉搏）期间发生的血压周期性变化的影响。这些大的变化可能会掩盖与大脑活动相关的较小的局部事件。我们开发了一种最小二乘回归算法，用于补偿脉冲引入的伪影。该过程考虑到心率的逐搏变异性以及受试者之间和记录条件之间脉搏形状的差异。
Various factors, including variations in the concentration of hemoglobin, determine changes in the transparency of living tissue to near-infrared light. Hence, optical measures have been proposed as a noninvasive method for investigating regional changes in brain activity. However, the amount of near-infrared light traversing a region of the head is also influenced by the periodic changes in blood pressure that occur during the cardiac cycle (pulse). These large changes may obscure smaller, localized events associated with brain activity. We developed a least-squares regression algorithm for compensating for the artifact introduced by the pulse. This procedure takes into account beat-to-beat variability in heart rate and differences in the shape of the pulse among subjects and among recording conditions.