GENETIC AND BEHAVIORAL-TESTS OF THE MCMANUS HYPOTHESIS RELATING RESPONSE TO SELECTION FOR LATERALIZATION OF HANDEDNESS IN MICE TO DEGREE OF HETEROZYGOSITY
GENETIC AND BEHAVIORAL-TESTS OF THE MCMANUS HYPOTHESIS RELATING RESPONSE TO SELECTION FOR LATERALIZATION OF HANDEDNESS IN MICE TO DEGREE OF HETEROZYGOSITY
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DOI：
10.1007/bf01067444
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发表时间：
1993-07-01
影响因子：
2.6
通讯作者：
NEUMANN, PE
中科院分区：
文献类型：
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作者：
COLLINS, RL;SARGENT, EE;NEUMANN, PE
McManus提出了一个遗传假说来解释选择性培育的H1和LO系小鼠偏侧化的差异。它指出，偏侧化是杂合性的一个功能。具体地说，它预测（a）HI系将比LO系更杂合和（B）具有更大平均杂合性（AH）的群体将更强烈地偏侧化。遗传和行为预测都在这里进行了测试。使用毛色和生化变体的结果表明，HI系中的AH略小于（不大于）LO系中的AH。HET对照小鼠和HI通过LO相互杂交的惯用手，其中AH大于HI系的惯用手，表现出减少的（不是更大的）偏侧化。结果拒绝杂合性假说。一个模型的遗传人类的惯用手，占难以检测的遗传差异程度的不对称性。
McManus advanced a genetic hypothesis to explain differences of lateralization between HI and LO lines of mice selectively bred for degree of handedness. It states that lateralization is a function of heterozygosity. Specifically it predicts that (a) the HI line will be more heterozygous than the LO line and (b) populations with a greater average heterozygosity (AH) will be more strongly lateralized. Both genetic and behavioral predictions were tested here. Results using coat color and biochemical variants show that AH in the HI line is somewhat less (not greater) than that in the LO line. The handedness of HET control mice and HI by LO reciprocal hybrids, where AH is greater than that of the HI line, exhibits lessened (not greater) lateralization. Results reject the heterozygosity hypothesis. A model for the inheritance of human handedness that accounts for difficulty in detecting heritable differences in degree of asymmetry is presented.