Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis
Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis
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DOI：
10.1046/j.1468-1331.2001.00232.x
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发表时间：
2001-07-01
影响因子：
5.1
通讯作者：
Sellebjerg, F
中科院分区：
文献类型：
--
作者：
Jensen, J;Krakauer, M;Sellebjerg, F
CD154 （cd40配体，gp39）在活化的T细胞上表达，在T细胞依赖性免疫反应中至关重要，并可能参与多发性硬化症（MS）的发病机制。我们用流式细胞术研究了MS患者脑脊液和外周血T细胞CD154的表达，发现继发性进展性MS （SPMS）患者血液中CD4和CD8 T细胞均有CD154的组成性表达。在复发-缓解型MS （RRMS）或提示脱髓鞘疾病的临床孤立综合征（CIS）患者中未观察到构成性CD154表达。体外活化后CD154。然而，CIS或RRMS患者的T细胞表达比例高于健康对照组。这些结果表明，CD154参与MS的发病机制，从复发缓解到继发性进展病程的转变可能与构成性、全身性CD154表达有关。
CD154 (CD40-ligand, gp39), expressed on activated T cells, is crucial in T cell-dependent immune responses and may be involved in the pathogenesis of multiple sclerosis (MS). We studied cerebro-spinal fluid and peripheral blood T cell expression of CD 154 in MS by flow cytometry, Patients with secondary progressive MS (SPMS) had constitutive CD154 expression on CD4 and CD8 T cells in blood. Constitutive CD154 expression was not observed in patients with relapsing-remitting MS (RRMS) or clinically isolated syndromes (CIS) suggestive of demyelinating disease. After ex vivo activation CD154 was. however, expressed on a higher percentage of T cells from patients with CIS or RRMS than from healthy control subjects. These results suggest involvement of CD154 in the pathogenesis of MS, and the shift from a relapsing-remitting to a secondary progressive disease course may be associated with constitutive, systemic CD154 expression.