Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats
Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats
复制标题
DOI：
10.1016/j.etp.2009.08.006
复制
发表时间：
2010-11-01
影响因子：
--
通讯作者：
Bhadauria, Monika
中科院分区：
文献类型：
--
作者：
Bhadauria, Monika
大黄素（1,3,8-三羟基-6-甲基蒽醌）的保护作用。对对乙酰氨基酚诱导的大鼠生化和组织学改变进行了评价。对乙酰氨基酚（2 g/kg, po）给药24 h后血清转氨酶、碱性磷酸酶、乳酸脱氢酶、血清胆红素和血清蛋白的释放显著升高，同时血红蛋白和血糖降低。毒物暴露增强了脂质过氧化和谷胱甘肽状态，改变了腺苷三磷酸酶、酸性磷酸酶、碱性磷酸酶以及肝脏和肾脏的主要细胞成分（蛋白质、糖原和总胆固醇）的活性。给药24小时后，大黄素（20、30和40 mg/kg， po）通过保护对乙酰氨基酚引起的各种血液和组织生化指标的改变，显著降低了毒性。对乙酰氨基酚引起肝脏组织损伤。大黄素治疗后有一定程度的保护作用，呈剂量依赖性。30和40 mg/kg剂量的大黄素与水飞蓟素（50 mg/kg, po）一样，能有效逆转对乙酰氨基酚引起的毒性事件。由此可见，30 mg/kg （po）剂量的大黄素对对乙酰氨基酚毒性具有最佳的肝保护能力。2009爱思唯尔有限公司版权所有。
Protective effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of Ventilago madraspatana Gaertn., was evaluated against acetaminophen-induced biochemical and histological alterations in rats. Acetaminophen (2 g/kg, po) administration caused significant elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase, serum bilirubin and serum protein with concomitant decrease in hemoglobin and blood sugar after 24 h of its administration. Toxicant exposure intensified the lipid peroxidation and altered glutathione status, activities of adenosine triphosphatase, acid phosphatase, alkaline phosphatase as well as major cellular constituents i.e., protein, glycogen and total cholesterol in liver and kidney. Treatment of emodin (20, 30 and 40 mg/kg, po) significantly lessened the toxicity by protecting acetaminophen-induced alterations in various blood and tissue biochemical variables after 24h of its administration. Acetaminophen administration initiated histological damage in liver. Some degree of protection was seen after emodin therapy in a dose-dependent manner. Emodin at doses of 30 and 40 mg/kg effectively reversed toxic events induced by acetaminophen as same as silymarin (50 mg/kg, po). Thus, the study concluded that emodin at a dose of 30 mg/kg (po) possesses optimum hepatoprotective ability against acetaminophen-induced toxicity. (C) 2009 Elsevier GmbH. All rights reserved.