Effect of experimental influenza A infection on systemic immune and inflammatory parameters in allergic and nonallergic adult subjects
Effect of experimental influenza A infection on systemic immune and inflammatory parameters in allergic and nonallergic adult subjects
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DOI：
10.1016/s1081-1206(10)62263-6
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发表时间：
2001-12-01
影响因子：
5.9
通讯作者：
Skoner, DP
中科院分区：
文献类型：
--
作者：
Gentile, DA;Doyle, WJ;Skoner, DP
背景资料：病毒性上呼吸道感染的经济影响和医疗并发症发生率已得到充分证实，但对呼吸道病毒的许多生理、炎症和免疫反应直到最近才得到研究。以往的研究表明，在实验性鼻病毒39感染过程中，变应性鼻炎（AR）和非变应性鼻炎（NAR）受试者的全身免疫和炎症反应存在差异。目的：本研究的目的是比较血清阴性AR和NAR受试者对实验性甲型流感病毒（FLU）攻击的选择性全身免疫和炎症反应。在基线（研究第0天）和3，6，18和31天后，鼻内流感病毒的挑战和白细胞组胺释放，血清免疫球蛋白，血浆histamin.Results：所有受试者被感染，表现为鼻分泌物中的病毒脱落和/或血清转化。流感病毒感染引起自发白细胞组胺释放减少和抗免疫球蛋白E诱导的白细胞组胺释放增加，这在感染后至少1个月是明显的，但血清免疫球蛋白或血浆组胺没有引起显着变化。AR和NAR受试者之间没有差异的任何研究parameters.Conclusions：结果表明，鼻内挑战与FLU诱导白细胞组胺释放的变化，但不是其他全身免疫和炎症反应。
Background: The economic impact and medical complication rate of viral upper respiratory infections are well documented, but many of the physiologic, inflammatory, and immune responses to respiratory viruses have only recently been investigated. A previous study demonstrated differential systemic immune and inflammatory responses in allergic rhinitis (AR) and nonallergic rhinitis (NAR) subjects during experimental infection with rhinovirus-39.Objective: The purpose of this study was to compare selected systemic immune and inflammatory responses to experimental influenza A virus (FLU) challenge in seronegative AR and NAR subjects,Methods: Peripheral blood was obtained at baseline (study day 0) and 3, 6, 18, and 31 days after intranasal FLU challenge and assayed for leukocyte histamine release, serum immunoglobulins, and plasma histamine.Results: All subjects were infected, as manifested by viral shedding in nasal secretions and/or seroconversion. FLU infection induced decreases in spontaneous leukocyte histamine release and increases in anti-immunoglobulin E-induced leukocyte histamine release, which were evident at least I month after infection, but caused no significant changes in serum immunoglobulins or plasma histamine. There were no differences between AR and NAR subjects for any of the study parameters.Conclusions: The results show that intranasal challenge with FLU induces changes in leukocyte histamine release, but not other systemic immune and inflammatory responses.