Creation of two tomographic voxel models of paediatric patients in the first year of life
Creation of two tomographic voxel models of paediatric patients in the first year of life
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DOI：
10.1088/0031-9155/47/17/307
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发表时间：
2002-09-07
影响因子：
3.5
通讯作者：
Bolch, WE
中科院分区：
文献类型：
--
作者：
Nipper, JC;Williams, JL;Bolch, WE
基于CT或MRI医学图像的区域分割的层析计算模型越来越多地被提出作为用于辐射剂量学研究的当前程式化的人体解剖学数学模型的替代。虽然已经投入了很大的努力对成人模型的创建，很少有研究已经开始，以解决模型支持儿科放射剂量测定的需要。在这项研究中，两个断层扫描模型创建使用自动和手动分割的组合，通过程序创建的内部使用IDL版本5.5。第一个模型是一个正常的6天的女性新生儿，由一个512 × 512 × 485的数据阵列。该模型每隔1 mm获取一层CT切片，定义了66个不同的解剖区域。第二个模型是发育相当于2个月男性的患者，并保存为512 x 512 x 438数据阵列。该受试者在肠道、肾脏、肝脏和脾脏内出现重度组织水肿。因此，该模型被认为是来自预期接受大于正常数量的诊断性X射线检查的患者亚群的重症儿童的代表。两个模型的体素体积分别为0.35 mm（3）和0.30 mm（3），因此使这些模型成为儿科剂量测定应用中最详细的模型。UF新生儿模型与参考ORNL/MIRD模型中器官质量的比值范围为食管和小肠/结肠分别为1.2至1.7，下颌骨和肱骨分别为0.18至0.27。对于UF 2个月模型，UF模型与8周GSF BABY模型中器官质量的比值范围为锁骨和脾脏分别为3.7 - 5.2，肾上腺和肩胛骨分别为0.2 - 0.3。
Tomographic computational models, based on regional segmentation of CT or MRI medical images, have increasingly been proposed as replacements for current stylized mathematical models of human anatomy used in radiation dosimetry studies. While much effort has been devoted towards the creation of adult models, few research studies have been initiated to address the need for models supporting paediatric radiology dosimetry. In this study, two tomographic models were created using a combination of automatic and manual segmentation via a program created in-house using IDL version 5.5. The first model is of a normal 6 day female newborn, and consists of a 512 x 512 x 485 data array. The CT slices of this model were obtained every I mm, and 66 different anatomic regions were defined. The second model is of a patient developmentally equivalent to a 2 month male, and was saved as a 512 x 512 x 438 data array. This subject had severe tissue oedema within the gut, kidneys, liver and spleen. The model is thus considered representative of a critically ill child, from a patient subpopulation expected to receive a larger than normal number of diagnostic x-ray exams. The voxel volumes for the two models are 0.35 mm(3) and 0.30 mm(3), respectively, thus making these models the most detailed in existence for paediatric dosimetry applications. Ratios of organ masses for the UF newborn model to those within the reference ORNL/MIRD model range from highs of 1.2 to 1.7 for the oesophagus and small intestine/colon, respectively, to lows of 0.18 to 0.27 for the mandible and humeri, respectively. For the UF 2 month model, ratios of organ masses in the UF model to those in the 8 week GSF BABY model ranged from highs of 3.7 to 5.2 for the clavicles and spleen, respectively, to lows of 0.2 to 0.3 for the adrenals and scapulae, respectively.