REGIOSPECIFIC SYNTHESIS OF MITOSENES BY A NEW BROMOQUINONE-ENAMINE ANNULATION REACTION
REGIOSPECIFIC SYNTHESIS OF MITOSENES BY A NEW BROMOQUINONE-ENAMINE ANNULATION REACTION
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DOI：
10.1016/s0040-4039(00)93988-1
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发表时间：
1992-01-21
影响因子：
1.8
通讯作者：
OSULLIVAN, PJ
中科院分区：
文献类型：
--
作者：
MURPHY, WS;OSULLIVAN, PJ
单溴代醌7到乙烯基氨基甲酸酯3的简便新的一锅环化提供了一条直接得到吡咯吲哚醌骨架的途径。将合成扩展到7-甲氧基亚甲基-2(R=OME，R1=R2=H)。对环化的机理进行了解释。
A facile new one pot annulation of monobromoquinones 7 to the vinylogous carbamate 3 provides a direct route to the pyrroloindoloquinone framework. Synthesis was extended to 7-methoxymitosene 2 (R = OMe, R1 = R2 = H). The mechanism of the annulation was elucidated.