Patterning the developing and regenerating olfactory system.
Patterning the developing and regenerating olfactory system.
复制标题
塑造嗅觉系统的发育和再生。
DOI：
10.1002/jcp.20888
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发表时间：
2007
影响因子：
5.6
通讯作者：
Schwarting,GeraldA
中科院分区：
文献类型：
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作者：
Henion,TimothyR;Schwarting,GeraldA
嗅觉系统是研究影响中枢神经系统中感觉轴突群引导至特定目标的因素的卓越模型。自从在啮齿类动物中首次发现大量气味受体（OR）基因家族以及随后发现这些分子直接影响靶向以来，已经确定了一些额外的嗅觉轴突引导线索。其中两种，肝配蛋白和信号蛋白，在其他系统中形成轴突连接模式方面具有完善的功能。此外，含乳糖胺的聚糖也是嗅觉轴突正确定位和维持所必需的，并且也可能在其他感觉区域发挥作用。现在很明显，这些分子和可能的其他分子需要与 OR 一起协调嗅觉系统特有的复杂的收敛和发散模式。 J.细胞。生理学。 210: 290–297, 2007。© 2006 Wiley-Liss, Inc.
The olfactory system is a remarkable model for investigating the factors that influence the guidance of sensory axon populations to specific targets in the CNS. Since the initial discovery of the vast odorant receptor (ORs) gene family in rodents and the subsequent finding that these molecules directly influence targeting, several additional olfactory axon guidance cues have been identified. Two of these, ephrins and semaphorins, have well‐established functions in patterning axon connections in other systems. In addition, lactosamine‐containing glycans are also required for proper targeting and maintenance of olfactory axons, and may also function in other sensory regions. It is now apparent that these and likely other additional molecules are required along with ORs to orchestrate the complex pattern of convergence and divergence that is unique to the olfactory system. J. Cell. Physiol. 210: 290–297, 2007. © 2006 Wiley‐Liss, Inc.