Near-infrared luminescent CaTiO(3):Nd(3+) nanofibers with tunable and trackable drug release kinetics.
Near-infrared luminescent CaTiO(3):Nd(3+) nanofibers with tunable and trackable drug release kinetics.
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具有可调谐和可追踪药物释放动力学的近红外发光 CaTiO3:Nd3 纳米纤维
DOI：
10.1039/c5tb01158b
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发表时间：
2015-10-07
期刊：
影响因子：
--
通讯作者：
Mao C
中科院分区：
文献类型：
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作者：
Li X;Zhang Q;Ahmad Z;Huang J;Ren Z;Weng W;Han G;Mao C
近红外(NIR)光谱中的750-850 nm(NIR-I)和1000-1400 nm(NIR-II)是生物组织的两个光学透明窗口，后者能够更深地穿透组织。在纳米医学领域，监测药物载体的药物释放仍然是一项艰巨的挑战。为了克服这一挑战，我们建议使用NIR I激发的多孔Nd3+掺杂CaTiO 3纳米纤维来携带药物，以测试通过检测NIR II发射强度来监测纳米纤维药物释放的概念。为此，我们首先通过加入形成胶束的表面活性剂Pluronic F127，然后通过退火来去除有机成分，利用电纺法制备了多孔Nd3+掺杂的CaTiO3纳米纤维。将模型药物布洛芬负载到多孔纳米纤维中后，通过检测纳米纤维的近红外发射来监测药物从纳米纤维释放到磷酸盐缓冲盐水(PBS)溶液中的情况。我们发现，药物分子从纳米纤维释放到PBS溶液中，触发了周围介质中羟基对NIR II发射的猝灭。因此，更多的药物释放对应着更多的NIR II发射强度的降低，使我们能够通过简单地检测纳米纤维的NIR II发射强度来监测药物释放。此外，我们还证明，调节形成胶束的表面活性剂Pluronic F127的量使我们能够调节纳米纤维的孔隙度，从而调节药物释放动力学。这项研究表明，掺Nd3+的CaTiO3纳米结构可以作为一种很有前途的药物传递平台，通过检测组织穿透近红外发射来监测药物释放动力学。
750–850 nm (NIR I) and 1000–1400 nm (NIR II) in the near infrared (NIR) spectra are two windows of optical transparency for biological tissues with the latter capable of penetrating tissue deeper. Monitoring drug release from the drug carrier is still a daunting challenge in the field of nanomedicine. To overcome such a challenge, we propose to use porous Nd3+-doped CaTiO3 nanofibers, which can be excited by NIR I to emit NIR II light, to carry drugs to test the concept of monitoring drug release from the nanofibers by detecting the NIR II emission intensity. Towards this end, we first used electrospinning to prepare porous Nd3+-doped CaTiO3 nanofibers by adding micelle-forming surfactant Pluronic F127, followed by annealing to remove the organic component. After a model drug, ibuprofen, was loaded into the porous nanofibers, the drug release from the nanofibers into the phosphate buffered saline (PBS) solution was monitored by detecting the NIR II emission from the nanofibers. We found that the release of the drug molecules from the nanofibers into the PBS solution triggers the quenching of NIR II emission by the hydroxyl groups in the surrounding media. Consequently, more drug release corresponded to more reduction in the intensity of the NIR II emission, allowing us to monitor the drug release by simply detecting the intensity of NIR II from the nanofibers. In addition, we demonstrated that tuning the amount of micelle-forming surfactant Pluronic F127 enabled us to tune the porosity of the nanofibers and thus the drug release kinetics. This study suggests that Nd3+ doped CaTiO3 nanostructures can serve as a promising drug delivery platform with the potential to monitor drug release kinetics by detecting the tissue-penetrating NIR emission.