AP lesions block suppression of estrous behavior, but not estrous cyclicity, in food-deprived Syrian hamsters.
AP lesions block suppression of estrous behavior, but not estrous cyclicity, in food-deprived Syrian hamsters.
复制标题
在食物匮乏的叙利亚仓鼠中，AP 损伤会抑制发情行为，但不会抑制发情周期。
DOI：
10.1152/ajpregu.1998.275.1.r158
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Schneider,JE
中科院分区：
文献类型：
--
作者：
Panicker,AK;Mangels,RA;Powers,JB;Wade,GN;Schneider,JE
食物剥夺抑制叙利亚仓鼠的排卵周期和发情行为。后发区（AP）的损伤阻止了食物剥夺仓鼠的发情行为的抑制，但它们不能阻止发情周期的抑制或由食物剥夺引起的跑轮活动的增加。食物剥夺或糖酵解和脂肪酸氧化药物抑制剂治疗降低下丘脑腹内侧（VMH）的雌激素受体免疫反应性（ERIR），增加弓形核（Arc）和后室旁细胞旁核（PaPo）的ERIR，但对后背部内侧杏仁核或前室旁细胞旁核的ERIR没有影响。AP病变阻止了食物剥夺引起的VMH ERIR的降低和Arc ERIR的增加，但它们没有阻止PaPo ERIR的增加。因此，无论食物剥夺产生了什么生理信号，完整的AP都是它们传递到控制发情行为、VMH ERIR和Arc ERIR的神经回路所必需的。AP对于将这些信息传递到控制发情周期、跑轮活动或PaPo ERIR的神经回路并不是必需的。
Food deprivation inhibits ovulatory cycles and estrous behavior in Syrian hamsters. Lesions of the area postrema (AP) prevented the suppression of estrous behavior in food-deprived hamsters, but they did not prevent the suppression of estrous cyclicity or the increase in running-wheel activity caused by food deprivation. Food deprivation or treatment with pharmacological inhibitors of glycolysis and fatty acid oxidation decreased estrogen-receptor immunoreactivity (ERIR) in the ventromedial hypothalamus (VMH), increased ERIR in the arcuate nucleus (Arc) and the posterior parvicellular paraventricular nucleus (PaPo), but had no effect on ERIR in the posterodorsal medial amygdala or the anterior parvicellular paraventricular nucleus. Lesions of the AP prevented the food deprivation-induced decrease in VMH ERIR and the increase in Arc ERIR, but they did not prevent the increase in ERIR in the PaPo. Thus, whatever physiological cues are produced by food deprivation, an intact AP is required for their transmission to the neural circuits controlling estrous behavior, VMH ERIR, and Arc ERIR. The AP is not essential for transmission of this information to the neural circuits controlling estrous cyclicity, running-wheel activity, or PaPo ERIR.