HEPATOCELLULAR-CARCINOMA - PILOT TRIAL OF TREATMENT WITH Y-90 MICROSPHERES
HEPATOCELLULAR-CARCINOMA - PILOT TRIAL OF TREATMENT WITH Y-90 MICROSPHERES
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DOI：
10.1148/radiology.172.3.2549567
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发表时间：
1989-09-01
期刊：
影响因子：
19.7
通讯作者：
RICHMONDCOX, K
中科院分区：
文献类型：
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作者：
HOULE, S;YIP, TCK;RICHMONDCOX, K
在一项对7名患者进行的初步研究中，评估了Y-90玻璃微球在治疗肝细胞癌中的潜在用途。Y-90微球经肝动脉导管注入。在这组患者中，对肝脏的吸收剂量在5,000到10,000 cGy之间，对肿瘤本身的吸收剂量高达32,000 cGy时没有观察到毒性。只有在较高的吸收剂量时才能看到肿瘤反应。只要能排除肝外分流，新的Y-90玻璃微球就可以安全地将大剂量的内照射输送到肝脏肿瘤。肝外分流将是这种形式的放射治疗的主要限制。
The potential use of yttrium-90 glass microspheres in the treatment of hepatocellular carcinoma was assessed in a pilot study of seven patients. The Y-90 microspheres were injected via a hepatic artery catheter. In this group of patients, no toxicity was observed for absorbed doses of between 5,000 and 10,000 cGy to the liver and up to 32,000 cGy to the tumor itself. Tumor response was seen only at the higher absorbed doses. The new Y-90 glass microspheres can safely deliver large doses of internal radiation to hepatic tumors as long as extrahepatic shunting can be excluded. Extrahepatic shunting will be the main limitation to this form of radiation therapy.