Sustained release from mesoporous nanoparticles: Evaluation of structural properties associated with release rate
Sustained release from mesoporous nanoparticles: Evaluation of structural properties associated with release rate
复制标题
DOI：
10.2174/156720108784911686
复制
发表时间：
2008-07-01
影响因子：
2.4
通讯作者：
Stromme, Maria
中科院分区：
文献类型：
--
作者：
Brohede, Ulrika;Atluri, Rambabu;Stromme, Maria
我们在此详细研究了氨基酸衍生的两亲性分子从具有不同结构性质的介孔纳米颗粒给药系统的内部孔结构中控制释放；即不同复杂程度的立方和六边形结构。所述纳米材料的内孔表面通过一锅法被胺基功能化。通过交流离子电流测量获得的释放曲线可以根据多孔纳米颗粒的特定结构和纹理参数（如孔隙几何形状和连通性）进行解释。结果表明，与三维介孔固体相比，二维结构中的扩散系数降低了4个数量级。从介孔材料AMS-9和AMS-8中观察到快速释放，其中结构缺陷的存在被认为导致后者的扩散系数略低。孔壁功能化的数量和模型药物上结合位点的数量对药物释放速度影响不大。
We present here a detailed study of the controlled release of amino acid derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties; namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one pot method. Release profiles obtained by Alternating Ionic Current measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much as four orders of magnitude in 2-dimensional structures in comparison to 3-dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS-9 and AMS-8 where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. Amount of pore wall functionalisation and number of binding sites on the model drug are found to have little effect on the drug release rate.