Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China
Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China
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维生素D代谢和运输相关基因多态性及其与骨质疏松风险的关系：中国多中心前瞻性队列研究方案
DOI：
10.1136/bmjopen-2018-028084
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发表时间：
2019-11-01
期刊：
影响因子：
2.9
通讯作者：
Wang, Yong-Jun
中科院分区：
文献类型：
--
作者：
Wang, Jing;Shu, Bing;Wang, Yong-Jun
简介骨质疏松性骨折是导致残疾的最常见原因之一，也是世界许多地区医疗费用的主要贡献者。维生素D代谢和转运相关基因的多态与骨密度的变化和骨质疏松的风险有关。方法与分析中国社区骨质疏松症队列研究是一项针对中国常住中老年居民的观察性、纵向、多中心、前瞻性队列研究，自2016年起在6个城市开展。通过永久居民名单确定45岁至80岁的女性居民和50岁至80岁的男性居民。所有登记的参与者将完成关于他们个人特征和历史的问卷调查。测量他们腰椎和左髋部的骨密度，并评估血清骨代谢参数。将检测与维生素D代谢和运输相关的基因多态性，并分析它们与骨质疏松症和骨质疏松性骨折风险的关系。约18,000名 居民将参与这项研究。伦理与传播本研究获得上海中医药大学附属龙华医院制度伦理委员会批准(2016LCSY065)。研究结果将发表在同行评议的期刊上。本研究结果可望加深对中国地区中老年居民维生素D代谢及转运相关基因多态性与骨质疏松及骨质疏松性骨折发病风险之间关系的认识。试用注册号NCT02958020
Introduction Osteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis. Methods and analysis The China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45–80 years old and male residents aged 50–80 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18 000 residents will be involved in the study. Ethics and dissemination The study was approved by Institutional Ethics Board of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (2016LCSY065). Results will be published in peer-reviewed journals. The results of this study are expected to improve the understanding of the association between polymorphisms of genes related to vitamin D metabolism and transportation and the risk of osteoporosis and osteoporotic fracture among middle-aged and older residents of China. Trial registration number NCT02958020