Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion.
Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion.
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DOI：
10.2337/dc09-1185
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发表时间：
2009-12
期刊：
影响因子：
16.2
通讯作者：
Rother KI
中科院分区：
文献类型：
--
作者：
Brown RJ;Walter M;Rother KI
本研究的目的是确定人工甜味剂对人体葡萄糖、胰岛素和胰高血糖素样肽（GLP）-1的影响。在这项研究中，22名健康志愿者（平均年龄18.5 ± 4.2岁）接受了两次75 g口服葡萄糖耐量试验，频繁测量葡萄糖、胰岛素和GLP-1，持续180分钟。受试者在葡萄糖负荷前10分钟随机饮用240 ml无糖苏打水或碳酸水。摄入碳酸水和无糖苏打水后，血糖波动相似。无糖汽水后血清胰岛素水平趋于升高，但无统计学意义。与碳酸水（AUC 16.2 ± 9.0 pmol/l/180 min; P = 0.003）相比，饮食苏打水（AUC 24.0 ± 15.2 pmol/l/180 min）的GLP-1峰值和曲线下面积（AUC）显著更高。人工甜味剂与葡萄糖协同作用，以增强GLP-1在人体内的释放。GLP-1分泌的增加可能是通过人工甜味剂刺激L细胞上的甜味受体介导的。
The goal of this study was to determine the effect of artificial sweeteners on glucose, insulin, and glucagon-like peptide (GLP)-1 in humans. For this study, 22 healthy volunteers (mean age 18.5 ± 4.2 years) underwent two 75-g oral glucose tolerance tests with frequent measurements of glucose, insulin, and GLP-1 for 180 min. Subjects drank 240 ml of diet soda or carbonated water, in randomized order, 10 min prior to the glucose load. Glucose excursions were similar after ingestion of carbonated water and diet soda. Serum insulin levels tended to be higher after diet soda, without statistical significance. GLP-1 peak and area under the curve (AUC) were significantly higher with diet soda (AUC 24.0 ± 15.2 pmol/l per 180 min) versus carbonated water (AUC 16.2 ± 9.0 pmol/l per 180 min; P = 0.003). Artificial sweeteners synergize with glucose to enhance GLP-1 release in humans. This increase in GLP-1 secretion may be mediated via stimulation of sweet-taste receptors on L-cells by artificial sweetener.