Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions
Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions
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DOI：
10.1016/0955-0674(92)90108-o
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发表时间：
1992-01-01
影响因子：
7.5
通讯作者：
Yonemura, Shigenobu
中科院分区：
文献类型：
--
作者：
Tsukita, Shoichiro;Tsukita, Sachiko;Yonemura, Shigenobu
细胞-细胞黏附连接是钙粘附素介导的细胞黏附的部位，肌动蛋白细丝通过其发达的质膜底膜与质膜紧密相连。最近的研究集中在粘附性连接底膜中钙粘附素和肌动蛋白细丝之间的分子连接，以了解这些底膜构成蛋白在基于钙粘附素的细胞黏附的调节和信号转导中的功能。
The cell—cell adherens junction is a site for cadherin-mediated cell adhesion where actin filaments are densely associated with the plasma membrane through its well-developed plasmalemmal undercoat. Recent research has focused on the molecular linkage between cadherins and actin filaments in the undercoat of adherens junctions in order to understand the functions of these undercoat-constitutive proteins in the regulation and signal transduction of cadherin-based cell adhesion.