Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder
Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder
复制标题
DOI：
10.1176/appi.ajp.160.6.1078
复制
发表时间：
2003-06-01
影响因子：
17.7
通讯作者：
Clark, D
中科院分区：
文献类型：
--
作者：
Tarter, RE;Kirisci, L;Clark, D
目的：这项纵向研究有三个目的：1）确定在多大程度上，男孩在高平均风险和低平均风险的物质使用障碍的不同的结构上的神经行为去抑制，2）评估能力的神经行为去抑制预测物质使用频率在16岁，和3）证明效用的神经行为去抑制在预测物质使用障碍。方法：作者从情感、行为和认知的测量中得出了神经行为去抑制指数。神经行为去抑制评分被用来区分青少年在高和低的平均风险的物质使用障碍和预测物质使用频率后4-6年和物质使用disorder后7-9 years.Results：神经行为障碍评分显着区分男孩在高的平均风险，从那些在低的平均风险，在10-12岁。16岁时的神经行为去抑制，结合物质使用频率和风险状态组，预测19岁时的物质使用障碍，准确率为85%，占药物使用筛查量表总体问题密度评分方差的50%。神经行为去抑制是一个更强的预测物质使用障碍（比值比= 6.83）比物质消费频率（比值比= 3.19）。结论：横向和纵向分析表明，神经行为去抑制是一个组成部分，在早期的物质使用障碍发病的倾向。
Objective: This longitudinal study had three aims: 1) determine the extent to which boys at high average risk and low average risk for substance use disorder differ on a construct of neurobehavioral disinhibition, 2) evaluate the capacity of neurobehavioral disinhibition to predict substance use frequency at age 16, and 3) demonstrate the utility of neurobehavioral disinhibition in predicting substance use disorder.Method: The authors derived an index of neurobehavioral disinhibition from measures of affect, behavior, and cognition. The neurobehavioral disinhibition score was used to discriminate youth at high and low average risk for substance use disorder and to predict substance use frequency after 4-6 years and substance use disorder after 7-9 years.Results: The neurobehavioral disorder score significantly discriminated boys at high average risk from those at low average risk at ages 10-12. Neurobehavioral disinhibition at age 16, in conjunction with substance use frequency and risk status group, predicted substance use disorder at age 19 with 85% accuracy and accounted for 50% of the variance in Drug Use Screening Inventory overall problem density score. Neurobehavioral disinhibition was a stronger predictor of substance use disorder (odds ratio = 6.83) than substance consumption frequency (odds ratio = 3.19).Conclusions: Cross-sectional and longitudinal analyses indicated that neurobehavioral disinhibition is a component of the liability to early age at onset of substance use disorder.