PARITY IN RELATION TO MORTALITY AND CANCER INCIDENCE - A PROSPECTIVE-STUDY OF NORWEGIAN WOMEN
PARITY IN RELATION TO MORTALITY AND CANCER INCIDENCE - A PROSPECTIVE-STUDY OF NORWEGIAN WOMEN
复制标题
DOI：
10.1093/ije/23.4.691
复制
发表时间：
1994-08-01
影响因子：
7.7
通讯作者：
NILSSEN, S
中科院分区：
文献类型：
--
作者：
KVALE, G;HEUCH, I;NILSSEN, S
背景很少有关于生育与总死亡率、死因特异性死亡率和癌症发病率的前瞻性研究发表。本文的目的是研究这些关系在一个大队列的挪威women. Methods。通过对63 090名妇女的访谈获得了有关生殖因素的信息。1961-1980年随访期间的所有死亡和癌症病例分别通过与挪威中央统计局和癌症登记处的档案链接获得。与产次的关系通过分层逻辑回归进行评估。对于脑血管病和缺血性心脏病，在队列的老年部分中观察到死亡率随产次增加而增加的中度但高度显著的积极趋势。死于疾病的人？呼吸系统疾病和自杀在未生育妇女中最常见。在乳腺癌、子宫体癌和卵巢癌以及黑色素瘤和非黑色素瘤皮肤癌中观察到与产次的负相关。在所有年龄组中观察到子宫颈癌、老年妇女呼吸系统癌以及队列中年轻部分的胰腺癌和多发性骨髓瘤的正相关性。结果不支持之前关于与肝癌或胆囊癌呈阳性相关的报道。结论。这项研究支持了经产妇女缺血性心脏病风险增加的证据，这在以前的三项小型前瞻性研究中已经观察到。它证实了早先关于产次高的妇女患乳腺癌、子宫体癌和卵巢癌风险低的观察结果。
Background. Few prospective studies relating childbearing to total and cause-specific mortality and cancer incidence have been published. The purpose of this paper was to examine these relations in a large cohort of Norwegian women.Methods. Information on reproductive factors was obtained through interviews with 63 090 women. All deaths and cancer cases during follow-up, 1961-1980, were obtained by linkage to the files at the Central Bureau of Statistics and the Cancer Registry of Norway, respectively. Associations with parity were assessed by stratified logistic regression.Results. For cerebrovascular and ischaemic heart disease, moderate but highly significant positive trends of increasing mortality with increasing parity were observed in the older part of the cohort. Deaths from diseases of ?he respiratory system and suicide were most common among nulliparous women. Inverse associations with parity were observed for cancers of the breast, corpus uteri and ovaries as well as for melanoma and non-melanoma skin cancers. Positive associations were observed for cancer of the cervix uteri in all age groups, for cancer of the respiratory system among older women and for pancreatic cancer and multiple myelomas in the younger part of the cohort. The results gave no support to previous reports of positive associations with cancer of the liver or gallbladder.Conclusions. The study supports evidence of an increased risk of ischaemic heart disease in multiparous women, which had been observed previously in three smaller prospective studies. It confirms earlier observations of low risks of cancer of the breast, corpus uteri and ovaries in women with high parity.