The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs
The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs
复制标题
氯化镧对宫颈癌细胞增殖和凋亡的影响：let-7a和miR-34a microRNA的参与
DOI：
10.1007/s10534-015-9872-6
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发表时间：
2015-10-01
期刊：
影响因子：
3.5
通讯作者：
Guo, Fei
中科院分区：
文献类型：
--
作者：
Yu, Lingfang;Xiong, Jieqi;Guo, Fei
镧系元素具有多种生物效应，其化合物的抗癌潜力已被广泛研究。然而，潜在的机制在很大程度上仍不清楚。在本研究中，我们认为La离子可以影响介导宫颈癌细胞凋亡的增殖和凋亡相关的microRNAs、let-7a和miR-34a的水平。结果表明，LaCl3通过调控LET-7a、miR-34a及其下游基因抑制宫颈癌细胞的增殖，并诱导其在体内和体外的凋亡。本研究为氯化镧的抗癌机制部分归因于miRNAs调控提供了新的证据，为氯化镧作为抗癌药物的临床应用奠定了实验基础。
Lanthanide elements have been documented to possess various biologic effects, and their compounds have been studied intensely for their anti-cancer potential. However, the underlying mechanisms remain largely unknown. In the present study, we propose that the levels of proliferation and apoptosis related microRNAs (miRNAs), let-7a and miR-34a, which mediate the apoptosis of cervical cancer cells, can be affected by the lanthanum ion. Our data showed that LaCl3inhibited the proliferation and induced the apoptosis of cervical cancer cells both in vivo and in vitro by regulating let-7a, miR-34a and their downstream genes. This study provides novel evidence demonstrating that the anticancer mechanism of lanthanum chloride is partially attributed to miRNAs regulation and establishes an experimental basis for the clinical application of lanthanum chloride as an anti-cancer drug.