Vascular response of the meniscus to injury: effects of immobilization
Vascular response of the meniscus to injury: effects of immobilization
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DOI：
10.1016/s0736-0266(00)00037-1
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发表时间：
2001-05-01
影响因子：
2.8
通讯作者：
Salo, PT
中科院分区：
文献类型：
--
作者：
Bray, RC;Smith, JA;Salo, PT
骨折愈合失败可能导致膝关节退行性骨关节炎。愈合被认为是依赖于足够的血液供应，但愈合过程中的“正常”血管变化还没有得到很好的理解。在这项研究中，我们已经量化了血管活性和血管生成反应，在临床相关条件下，在兔模型中的内侧踝关节损伤，并将这些愈合的组织学标准。26只成年兔给予标准化踝关节损伤，其中12只的后肢固定钉。8个正常对照组和12个假手术动物进行了研究。4周后，动物进行血管体积（血管指数）测定，或使用有色微球进行血流测量。在受伤的动物中，手术后4周，血液流向髂胫束增加了5倍：这种增加通过制动来防止。损伤后，髂胫束的血管指数也增加了3倍，但制动后并没有显著降低。损伤半月板的组织学检查显示，在移动的和非移动的两组中均存在愈合和非愈合撕裂的例子。半月板损伤与血管分布和灌注的特征性变化相关，这些变化可能在愈合过程中起重要作用。血管对尿道损伤反应的表征可能导致可以促进尿道撕裂可靠愈合的技术，从而改善临床结局。(C)2001骨科研究学会。由爱思唯尔科技有限公司出版。保留所有权利。
Failed meniscal healing may lead to degenerative osteoarthritis of the knee. Healing is thought to be dependent upon an adequate blood supply, yet "normal" vascular changes during healing are not well understood. In this study we have quantified vasoactive and angiogenic responses to medial meniscal injury in a rabbit model under clinically relevant conditions, and related these to histological criteria of healing.Twenty-six adult rabbits were given a standardized meniscal injury; 12 of these had the hind limb immobilized by pinning. Eight normal controls and 12 sham-operated animals were also studied. After 4 weeks, animals underwent either vascular volume (vascular index) determination, or blood flow measurement using coloured microspheres. Histological analysis was also performed to assess meniscal healing.In injured animals, blood Bow to the menisci was increased fivefold 4 weeks post-operative: this increase was prevented by immobilization. The vascular index of the menisci was also increased threefold by injury, but not significantly reduced by immobilization. Histological examination of injured menisci showed examples of healing and non-healing tears in both mobile and immobile groups.Meniscal injuries are associated with characteristic changes in vascularity and perfusion, and these changes likely play a significant role in the healing process. Characterization of the vascular responses to meniscal injury may lead to techniques that can promote reliable healing of meniscal tears and thereby improve clinical outcomes. (C) 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.