Longitudinal associations between ultra-processed foods and blood lipids in childhood
Longitudinal associations between ultra-processed foods and blood lipids in childhood
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DOI：
10.1017/s0007114520001233
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发表时间：
2020-08-14
影响因子：
3.6
通讯作者：
Vitolo, Marcia R.
中科院分区：
文献类型：
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作者：
Leffa, Paula S.;Hoffman, Daniel J.;Vitolo, Marcia R.
新出现的证据表明，超加工食品(UPF)的消费在慢性疾病的发展中发挥了作用，但其对儿童影响的证据有限。我们的目标是研究UPF摄入量的纵向趋势，并确定它们对幼儿血脂的影响。本研究是对来自巴西阿雷格里港的儿童(N308)进行的随机实地试验的后续研究。在3岁和6岁时，使用两次24小时回忆收集膳食摄入量，并根据NOVA系统对UPF的消费量进行分类，NOVA系统是基于工业食品加工的程度和目的的食品分类。在6岁时，进行血液测试以测量血脂水平。在随访期内，UPF对总能量摄入量的贡献增加了10%，从3岁的43中心点4%增加到6岁的47中心点7%。线性回归模型显示，UPF消费量最高的三分位数3岁儿童的总胆固醇水平(TC；β0中心点22 mm o l/L；95%CI 0中心点04，0中心点39)和6岁时的TAG水平(β0中心点11 mm o l/L，95%CI 0中心点01，0中心点20)均高于最低三分位数儿童。UPF对TC(β0中心点07 mm o l/L，95%CI 0中心点00，0中心点14)和TAG(β0中心点04 mm o l/L，95%CI 0中心点01，0中心点07)的绝对增量呈正剂量反应。根据我们的数据，UPF的消费量随着时间的推移显著增加，并与低收入社区儿童的高血脂水平有关。我们的发现强调了需要采取有效的策略，将UPF在早期生活中的消耗量降至最低。
Emerging evidence suggests that the consumption of ultra-processed foods (UPF) plays a role in the development of chronic diseases, but evidence of their influence in children is limited. Our objective was to study longitudinal trends of UPF intake and determine their impact on blood lipids in young children. The present study was a follow-up of a randomised field trial of children (n308) from Porto Alegre, Brazil. Dietary intake was collected using two 24-h recalls at 3 and 6 years of age, and consumption of UPF was classified according to the NOVA system, a food classification based on the extent and purpose of industrial food processing. At age 6 years, blood tests were performed to measure lipid profile. Contribution of UPF to total energy intake increased by 10 % during the follow-up period, from 43 center dot 4 % at 3 years to 47 center dot 7 % at 6 years of age. Linear regression models showed that children in the highest tertile of UPF consumption at age 3 years had higher levels of total cholesterol (TC;beta 0 center dot 22 mmol/l; 95 % CI 0 center dot 04, 0 center dot 39) and TAG at age 6 years (beta 0 center dot 11 mmol/l, 95 % CI 0 center dot 01, 0 center dot 20) compared with those in the lowest tertile. A positive dose-response was observed for an absolute increment of 10 % of UPF on TC (beta 0 center dot 07 mmol/l, 95 % CI 0 center dot 00, 0 center dot 14) and TAG (beta 0 center dot 04 mmol/l, 95 % CI 0 center dot 01, 0 center dot 07). Based on our data, consumption of UPF increased significantly over time and was associated with higher blood lipid levels in children from a low-income community. Our findings highlight the need for effective strategies to minimise the consumption of UPF in early life.