Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate.
Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate.
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DOI：
10.31491/apt.2021.03.051
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发表时间：
2021-03-29
期刊：
影响因子：
--
通讯作者：
Jiang Z
中科院分区：
文献类型：
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作者：
Ellis M;Ladiges W;Jiang Z
身体机能的丧失，如在人类中所见的握力和整体身体健康的下降，通常被认为是衰老的结果。通常没有治疗方法来延迟或减少这些变化或增加对它们的适应力。在这项初步研究中，给予20月龄雄性和雌性C57 BL/6小鼠标准小鼠饲料或含有雷帕霉素（14 ppm）、阿卡波糖（1000 ppm）和苯丁酸盐（1000 ppm）的配制小鼠饲料，或含有每种药物一半剂量的饲料，持续3个月。在研究结束时，对旋转棒和握力测试的表现进行了比较。一般而言，喂食全剂量药物混合饲料的小鼠在这些测定中表现更好，喂食全剂量混合饲料的雌性动物的转棒性能显著改善，喂食全剂量混合饲料的雄性动物和喂食低剂量混合饲料的雌性动物的握力显著改善。这些观察结果为以下概念提供了支持：使用针对多种衰老途径的药物鸡尾酒进行短期治疗可以增加对衰老的恢复力，并表明这种原型鸡尾酒可能是临床治疗策略的一部分，用于延迟与年龄相关的身体表现丧失。
Loss of physical performance, as seen in humans by decreased grip strength and overall physical fitness, is generally accepted to be a consequence of aging. Treatments to delay or reduce these changes or increase resilience to them are generally not available. In this preliminary study, 20-month-old male and female C57BL/6 mice were given either a standard mouse diet or a formulated mouse diet containing rapamycin (14 ppm), acarbose (1000 ppm), and phenylbutyrate (1000 ppm), or a diet containing one half dose of each drug, for 3 months. At the end of the study, performance on a rotarod and grip strength test was compared. In general, mice fed the full dose drug cocktail diet performed better on these assays, with significant improvements in rotarod performance in females fed the full dose cocktail and in grip strength in males fed the full dose cocktail, and females fed the low dose cocktail. These observations provide support for the concept that short term treatment with a cocktail of drugs that targets multiple aging pathways can increase resilience to aging, and suggests that this prototype cocktail could be part of a clinical therapeutic strategy for delaying age-related loss of physical performance in people.