METAANALYSIS OF THE EFFECTS OF SOY PROTEIN-INTAKE ON SERUM-LIPIDS
METAANALYSIS OF THE EFFECTS OF SOY PROTEIN-INTAKE ON SERUM-LIPIDS
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DOI：
10.1056/nejm199508033330502
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发表时间：
1995-08-03
影响因子：
158.5
通讯作者：
COOKNEWELL, ME
中科院分区：
文献类型：
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作者：
ANDERSON, JW;JOHNSTONE, BM;COOKNEWELL, ME
背景在实验室动物中，大豆蛋白的消费，而不是动物蛋白，降低血清胆固醇浓度，但在人类的研究一直没有定论。在这项对38项对照临床试验的荟萃分析中，我们研究了人类大豆蛋白摄入量与血脂浓度之间的关系。我们使用随机效应模型来量化大豆蛋白摄入量对血脂的平均影响，并使用分层混合效应回归模型来预测作为研究特征函数的变化。在大多数研究中，当受试者摄入控制饮食和含大豆饮食时，能量、脂肪、饱和脂肪和胆固醇的摄入量相似;大豆蛋白的摄入量平均为每天47克。与对照组相比，摄入大豆蛋白后，血清脂质浓度发生了以下净变化：总胆固醇降低23.2毫克/分升（0.60 mmol/L; 95%置信区间，13.5至32.9 mg/dl [0.35至0.85 mmol/L]），或9.3%;低密度脂蛋白（LDL）胆固醇，每分升减少21.7毫克（0.56 mmol/L; 95%置信区间，11.2至31.7 mg/dl [0.30至0.82 mmol/L]），或12.9%;和甘油三酯，每分升减少13.3毫克（0.15mmol/L; 95%置信区间，0.3至25.7 mg/dl [0.003至0.29 mmol/L]），或10.5%，血清胆固醇和低密度脂蛋白胆固醇浓度的变化与初始血清胆固醇浓度直接相关（P
Background. In laboratory animals, the consumption of soy protein, rather than animal protein, decreases serum cholesterol concentrations, but studies in humans have been inconclusive. In this meta-analysis of 38 controlled clinical trials, we examined the relation between soy protein consumption and serum lipid concentrations in humans.Methods. We used a random-effects model to quantify the average effects of soy protein intake on serum lipids in the studies we examined and used hierarchical mixed-effects regression models to predict variation as a function of the characteristics of the studies.Results. In most of the studies, the intake of energy, fat, saturated fat, and cholesterol was similar when the subjects ingested control and soy-containing diets; soy protein intake averaged 47 g per day. Ingestion of soy protein was associated with the following net changes in serum lipid concentrations from the concentrations reached with the control diet: total cholesterol, a decrease of 23.2 mg per deciliter (0.60 mmol per liter; 95 percent confidence interval, 13.5 to 32.9 mg per deciliter [0.35 to 0.85 mmol per liter]), or 9.3 percent; low-density lipoprotein (LDL) cholesterol, a decrease of 21.7 mg per deciliter (0.56 mmol per liter; 95 percent confidence interval, 11.2 to 31.7 mg per deciliter [0.30 to 0.82 mmol per liter]), or 12.9 percent; and triglycerides, a decrease of 13.3 mg per deciliter (0.15 mmol per liter; 95 percent confidence interval, 0.3 to 25.7 mg per deciliter [0.003 to 0.29 mmol per liter]), or 10.5 percent, The changes in serum cholesterol and LDL cholesterol concentrations were directly related to the initial serum cholesterol concentration (P