The effect of inhaled nitric oxide on pulmonary function in preterm infants.
The effect of inhaled nitric oxide on pulmonary function in preterm infants.
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吸入一氧化氮对早产儿肺功能的影响。
DOI：
10.1038/sj.jp.7211830
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Martin,RJ
中科院分区：
文献类型：
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作者：
DiFiore,JM;Hibbs,AM;Zadell,AE;Merrill,JD;Eichenwald,EC;Puri,AR;Mayock,DE;Courtney,SE;Ballard,RA;Martin,RJ
目的：早产儿支气管肺发育不良（BPD）与肺泡生长受损、炎症和气道高反应性有关。在BPD动物模型中，吸入一氧化氮（NO）可促进肺泡生长，抑制气道平滑肌增殖。本研究旨在评估吸入NO对进展性BPD通气早产儿抵抗性和依从性的影响。研究设计：在7至21天的生命中，测量71名通气早产儿的呼气阻力和呼吸系统的依从性，≤32周妊娠，随机分为NO （n= 34）和安慰剂（n= 37），为期大于或等于24天。结果：基线呼气阻力（231±71 vs 215±76 cm H 2o−1 s−1）和依从性（0.49±0.14 vs 0.53±0.13 ml cm H 2o−1 kg−1）在安慰剂组和NO组之间具有可比性。在研究气体给药1小时、1周和2周时，no对呼气阻力或依从性没有影响。结论：NO对通气早产儿呼气阻力及依从性无中短期影响。
Objective:Bronchopulmonary dysplasia (BPD) in preterm infants is associated with impaired alveolar growth, inflammation and airway hyperreactivity. In animal models of BPD, inhaled nitric oxide (NO) improves alveolar growth and inhibits airway smooth muscle proliferation. This study was designed to assess the effect of inhaled NO on resistance and compliance in ventilated preterm infants with evolving BPD.Study Design:Expiratory resistance and compliance of the respiratory system were measured in 71 ventilated preterm infants,⩽ 32 weeks gestation, randomized to NO (n= 34) versus placebo (n= 37) for⩾ 24 days at 7 to 21 days of life.Result:At baseline expiratory resistance (231±71 versus 215±76 cm H 2 O l− 1 s− 1) and compliance (0.49±0.14 versus 0.53±0.13 ml cm H 2 O− 1 kg− 1) were comparable between placebo and NO groups, respectively. There was no effect of NO on expiratory resistance or compliance at 1 h, 1 week or 2 weeks of study gas administration.Conclusion:NO had no short-or medium-term effect on expiratory resistance or compliance in ventilated preterm infants.