Cerebellum volume and eyeblink conditioning in schizophrenia
Cerebellum volume and eyeblink conditioning in schizophrenia
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DOI：
10.1016/j.pscychresns.2007.06.001
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发表时间：
2008-04-15
影响因子：
2.3
通讯作者：
Hetrick, William P.
中科院分区：
文献类型：
--
作者：
Edwards, Chad R.;Newman, Sharlene;Hetrick, William P.
虽然越来越多的证据表明，小脑异常可能与精神分裂症的症状和病程有关，但很少有研究有与小脑完整性相关的结构和功能指数。本研究探讨了用眨眼条件反射(EBC)测量小脑特定亚区体积与小脑功能之间的关系。9名精神分裂症患者和6名健康对照参与者完成了大脑结构磁共振成像和延迟的EBC程序。对全脑、全小脑、小脑前小叶I-V和小脑后小叶VI-VII进行体积测量。与对照组相比，精神分裂症组的小脑前叶较小，EBC受损。在对照组，在配对试验中，较大的前体积与较早的条件性反应起始潜伏期和非条件性眨眼反应的幅度增加相关(即，当条件刺激和非条件刺激同时出现时)。小脑前部体积变小和EBC受损与精神分裂症相关的研究结果与非人类研究一致，表明小脑前部异常与延迟EBC缺陷有关。在精神分裂症组中，EBC指数与小脑体积之间缺乏显著的相关性，这表明小脑结构和功能之间存在异常关系。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Although accumulating evidence suggests that cerebellar abnormalities may be linked to the symptoms and course of schizophrenia, few studies have related structural and functional indices of cerebellar integrity. The present study examined the relationship between the volume of specific subregions of the cerebellum and cerebellar function, as measured by eyeblink conditioning (EBC). Nine individuals with schizophrenia and six healthy comparison participants completed structural magnetic resonance imaging of the brain and a delay EBC procedure. Volumetric measurements were taken for the whole brain, whole cerebellum, cerebellar anterior lobules I-V and posterior lobules VI-VII. The schizophrenia group had smaller cerebellar anterior lobes and exhibited impaired EBC relative to the comparison group. In the comparison group, larger anterior volume correlated with earlier conditioned response onset latencies and increased amplitudes of the unconditioned blink response during paired trials (i.e., when the conditioned and unconditioned stimuli co-occurred). The findings that smaller anterior cerebellar volumes and EBC impairments were associated with schizophrenia are consistent with non-human studies showing that anterior cerebellar abnormalities are associated with deficits in delay EBC. The lack of a significant correlation between indices of EBC and cerebellar volume within the schizophrenia group suggests an aberrant relationship between cerebellar structure and function. (C) 2007 Elsevier Ireland Ltd. All rights reserved.