Tendon tissue engineering with mesenchymal stem cells and biografts: an option for large tendon defects?
Tendon tissue engineering with mesenchymal stem cells and biografts: an option for large tendon defects?
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DOI：
10.2741/s3
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发表时间：
2009-06-01
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影响因子：
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通讯作者：
Ouyang, Hong Wei
中科院分区：
文献类型：
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作者：
Chen, Xiao;Zou, Xiao Hui;Ouyang, Hong Wei
在组织工程方法中，组织修复和再生的最重要因素是使用合适的细胞和支架。骨髓间充质干细胞（Mesenchymal stem cells，MSCs）是最有前途的种子细胞之一，其来源简单，在体内外均具有向肌腱细胞和多种间充质细胞分化的潜能。生物肌腱移植物是目前临床实践中最常见的选择，因为它们具有物理结构、强度和生物相容性。本文就近年来基于MSC的肌腱组织工程的研究成果及生物移植物的研究进展作一综述。
The most important factors in the tissue engineering approach to tissue repair and regeneration are the use of appropriate cells and scaffolds. Mesenchymal stem cells (MSCs) are one of the most promising seed cells, which can be easily derived and have the potential to differentiate into various mesenchymal cell types as well as tenocytes in vitro and in vivo. Biological tendon grafts are the most common choice in current clinical practice, as they possess physical structure, strength and biocompatibility. We review the latest research findings on MSC-based tendon tissue engineering and recent advances in biological graft research.