Immunologic and epidemiologic aspects of varicella infection acquired during infancy and early childhood.
Immunologic and epidemiologic aspects of varicella infection acquired during infancy and early childhood.
复制标题
婴儿期和幼儿期获得的水痘感染的免疫学和流行病学方面。
DOI：
10.1016/s0022-3476(82)80505-2
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Ogra,PL
中科院分区：
文献类型：
--
作者：
Baba,K;Yabuuchi,H;Takahashi,M;Ogra,PL
在日本一个半封闭的婴儿护理机构中，研究了三次水痘暴发期间一岁以下婴儿水痘带状疱疹感染的发展。在四年的时间里，许多居民的年龄从27天到32个月不等，检测皮肤对VZV抗原的反应性，以及VZV特异性抗体活性之前，期间和之后的水痘爆发。其中，85例受试者发生临床水痘，所有易感受试者的总体发病率为100%。所有2个月以下的婴儿都是在这种接触后感染的，尽管存在预先存在的母体抗体。小于2月龄的婴儿皮肤受累程度似乎较轻（<20个水疱），2至11月龄的受试者更常发生严重皮肤疾病（超过300个皮疹或融合性皮疹）。预先存在的抗体不能阻止疾病的发展，也不能改变抗体的程度或对随后感染的细胞免疫反应。然而，在2个月以下的婴儿中，发现感染后对VZV抗原的皮肤反应性峰值显著较低。
The development of varicella zoster infection was studied in a population of infants under one year of age during three outbreaks of varicella in a semi-closed domiciliary institution for infants in Japan. Over a period of four years, many residents ranging in age from 27 days to 32 months were tested for cutaneous reactivity to VZV antigen, and VZV-specific antibody activity before, during, and after each outbreak of varicella. Of these, 85 subjects developed clinical varicella, with an overall attack rate of 100% for all susceptible subjects. All the infants under 2 months of age were infected following such exposure, despite the presence of pre-existing maternal antibody. The degree of cutaneous involvement appeared to be milder (<20 vesicles) in infants less than 2 months of age, and severe cutaneous disease (with over 300 eruptions or confluent rash) occurred more frequently in subjects 2 to 11 months of age. Pre-existing antibody did not prevent development of illness, or alter the degree of antibody or cellular immune response to subsequent infection. However, the peak cutaneous reactivity to VZV antigen after infection was found to be significantly lower in infants under 2 months of age.