Accuracy of microvascular measurements obtained from micro-CT images.
Accuracy of microvascular measurements obtained from micro-CT images.
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DOI：
10.1007/s10439-010-0058-7
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发表时间：
2010-09
影响因子：
3.8
通讯作者：
Ritman, Erik L.
中科院分区：
文献类型：
--
作者：
Kline, Timothy L.;Zamir, Mair;Ritman, Erik L.
关键词：
微血管分支几何结构的早期变化及其对疾病灌注分布的相关影响，特别是那些不同分支世代受到不同影响的疾病，需要能够在广泛的尺度上分析完整的血管树。Micro-CT提供了一个很好的框架来分析微血管分支的几何形状。这样的分析需要开发能够准确表征分支性质的方法，例如微脉管系统的分支直径、长度、分支角度和分支互连性。本文的目的是报告两个人心肌内冠状动脉血管树模型的研究结果，其中微CT血管成像及其分析的准确性进行了测试，通过光学显微镜（作为“金标准”）的测量。提出了与血管腔的图像分割、血管树中心线提取、单个分支段测量以及补偿微型CT扫描仪的非理想调制传递函数相关的方法。提取的中心线准确地表征了血管树模型的层次结构的“父-分支”关系，其允许将每个分支间段的尺寸与光学测量方法进行比较。比较结果表明，两种方法的长度和直径测量接近理想的1：1关系。结合两个样本的结果，测量方法间差异的标准差为19 µm，用于测量分支间节段直径（范围为12 - 769 µm），172 µm用于测量分支间节段长度（范围为14 - 3252 µm）。这些结果表明，我们的micro-CT图像分析方法可以用来表征血管树的层次结构，并准确地测量分支间段的长度和直径。
Early changes in branching geometry of microvasculature and its associated impact on the perfusion distribution in diseases, especially those in which different branching generations are affected differently, require the ability to analyze intact vascular trees over a wide range of scales. Micro-CT offers an excellent framework to analyze the microvascular branching geometry. Such an analysis requires methods to be developed that can accurately characterize branching properties, such as branch diameter, length, branching angle, and branch interconnectivity of the microvasculature. The purpose of this article is to report the results of a study of two human intramyocardial coronary vascular tree casts in which the accuracy of micro-CT vascular imaging and its analysis are tested against measurements made through an optical microscope (used as the “gold-standard”). Methods related to image segmentation of the vascular lumen, vessel tree centerline extraction, individual branch segment measurement, and compensating for the non-ideal modulation transfer function of micro-CT scanners are presented. The extracted centerline accurately characterized the hierarchical structure of the vascular tree casts in terms of “parent–branch” relationships which allowed each interbranch segments’ dimensions to be compared to the optical measurement method. The comparison results show a close to ideal 1:1 relationship for both length and diameter measurements made by the two methods. Combining the results from both specimens, the standard deviation of the difference between measurement methods was 19 µm for the measurement of interbranch segment diameters (ranging from 12 to 769 µm), and 172 µm for the measurement of interbranch segment lengths (ranging from 14 to 3252 µm). These results suggest that our micro-CT image analysis method can be used to characterize a vascular tree’s hierarchical structure, and accurately measure interbranch segment lengths and diameters.
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影响因子：
10.6
作者：
Megalooikonomou V;Barnathan M;Kontos D;Bakic PR;Maidment AD
通讯作者：
Maidment AD
影响因子：
3.9
作者：
Lindquist, WB;Lee, SM;Spanne, P
通讯作者：
Spanne, P
影响因子：
6.2
作者：
Au, Oscar Kin-Chung;Tai, Chiew-Lan;Lee, Tong-Yee
通讯作者：
Lee, Tong-Yee
DOI：
10.2307/2987937
发表时间：
1983-01-01
期刊：
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES D-THE STATISTICIAN
影响因子：
--
作者：
ALTMAN, DG;BLAND, JM
通讯作者：
BLAND, JM
DOI：
10.1002/jmri.1880080608
发表时间：
1998-11-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
Hoogeveen, RM;Bakker, CJG;Viergever, MA
通讯作者：
Viergever, MA