Body burden levels of dioxin, furans, and PCBs among frequent consumers of Great Lakes sport fish
Body burden levels of dioxin, furans, and PCBs among frequent consumers of Great Lakes sport fish
复制标题
DOI：
10.1006/enrs.1998.3906
复制
发表时间：
1999-02-01
影响因子：
8.3
通讯作者：
Patterson, D
中科院分区：
文献类型：
--
作者：
Falk, C;Hanrahan, L;Patterson, D
二恶英、呋喃和多氯联苯（PCB）是有毒的，在环境中持久存在，并在生物中积累到对人类有害的浓度。垂钓者可能会通过食用受污染的五大湖（GL）鱼类接触这些残留物。GL五个州（威斯康星州、密歇根州、俄亥俄州、伊利诺伊州和印第安纳州）的卫生部门组成了一个联合会，研究密歇根湖、休伦湖和伊利湖鱼类消费者体内化学残留物的负担水平。1993年秋季，对钓鱼运动户进行了电话调查，以获得鱼类消费习惯和人口统计数据。从部分研究受试者中采集血样。分析了100份血清样本中的8种二恶英、10种呋喃和4种共面多氯联苯同系物。进行多元线性回归以评估以下协变量的可预测性：GL运动鱼类种类、年龄、BMI、性别、运动鱼类消费年数和湖泊。在100名受试者中，有58名男性; 35名消费密歇根湖的运动鱼，29名来自休伦湖，36名来自伊利湖。在过去12个月，GL运动鱼餐的整体平均消费量为43。平均而言，伊利湖的男性和女性消费者吃了更多的GL运动鱼，平均分别为57和42餐，比其他两个湖泊亚组的男性和女性。中位总二恶英毒性当量（TEq），总呋喃TEq，和共面PCB TEq的所有男性高于所有女性（P = 0.0001）。湖鳟鱼，鲑鱼，年龄，体重指数和性别是显着的回归预测的日志（共面多氯联苯）。湖鳟鱼，年龄，性别和湖泊的日志（总呋喃）显着回归预测。年龄是二恶英总含量的唯一重要预测因素。(C)北京：科学出版社.
Dioxins, furans, and polychlorinated biphenyls (PCBs) are toxic, persist in the environment, and bioaccumulate to concentrations that can be harmful to humans. Sport anglers may be exposed to these residues via consumption of contaminated Great Lakes (GL) fish. The Health Departments of five GL states, Wisconsin, Michigan, Ohio, Illinois, and Indiana, formed a consortium to study body burden levels of chemical residues in fish consumers of Lakes Michigan, Huron, and Erie. In Fall 1993, a telephone survey was administered to sport angler households to obtain fish consumption habits and demographics. A blood sample was obtained from a portion of the study subjects. One hundred serum samples were analyzed for 8 dioxin, 10 furan, and 4 coplanar PCB congeners. Multiple linear regression was conducted to assess the predictability of the following covariates: GL sport fish species, age, BMI, gender, years sport fish consumed, and lake. Of the 100 subjects, there were 58 men; 35 consumed sport fish from Lake Michigan, 29 from Lake Huron, and 36 from Lake Erie. The overall average number of GL sport fish meals consumed in the previous 12 months was 43. Lake Erie male and female consumers, on average, ate more GL sport fish, a mean of 57 and 42 meals, respectively, than men and women from the other two lake subgroups. Median total dioxin toxic equivalents (TEq), total furan TEq, and total coplanar PCB TEq were higher among all men than all women (P = 0.0001). Lake trout, salmon, age, BMI, and gender were significant regression predictors of log(total coplanar PCBs). Lake trout, age, gender, and lake were significant regression predictors of log(total furans). Age was the only significant predictor of total dioxin levels. (C) 1999 Academic Press.