PML Degradation: Multiple Ways to Eliminate PML.
PML Degradation: Multiple Ways to Eliminate PML.
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DOI：
10.3389/fonc.2013.00060
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发表时间：
2013
影响因子：
4.7
通讯作者：
Scaglioni PP
中科院分区：
文献类型：
--
作者：
Rabellino A;Scaglioni PP
早幼粒细胞白血病肿瘤抑制基因（PML）关键性地调节几种对抗肿瘤发生的细胞功能，如癌基因诱导的衰老、凋亡、对DNA损伤和对病毒感染的反应。PML缺陷通常通过涉及其异常泛素化和降解的机制发生在广泛的人类癌症中。此外，几种病毒编码通过降解PML促进病毒复制的病毒蛋白。这些观察结果表明，PML的恢复应导致有效的抗肿瘤作用或抗病毒反应。在这篇综述中，我们将总结PML降解的机制，目的是强调新的治疗策略，以触发PML的恢复。
The promyelocytic leukemia tumor suppressor gene (PML) critically regulates several cellular functions that oppose tumorigenesis such as oncogene-induced senescence, apoptosis, the response to DNA damage and to viral infections. PML deficiency occurs commonly in a broad spectrum of human cancers through mechanisms that involve its aberrant ubiquitination and degradation. Furthermore, several viruses encode viral proteins that promote viral replication through degradation of PML. These observations suggest that restoration of PML should lead to potent antitumor effects or antiviral responses. In this review we will summarize the mechanisms involved in PML degradation with the intent to highlight novel therapeutic strategies to trigger PML restoration.