PRENATAL AND POSTNATAL-DEVELOPMENT OF ADIPOSE-TISSUE AT 4 SITES IN THE GUINEA-PIG - EFFECT OF MATERNAL DIET RESTRICTION DURING THE 2ND-HALF OF PREGNANCY
PRENATAL AND POSTNATAL-DEVELOPMENT OF ADIPOSE-TISSUE AT 4 SITES IN THE GUINEA-PIG - EFFECT OF MATERNAL DIET RESTRICTION DURING THE 2ND-HALF OF PREGNANCY
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DOI：
10.1159/000177269
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发表时间：
1987-07-01
影响因子：
3.9
通讯作者：
DAY, KC
中科院分区：
文献类型：
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作者：
ASHWELL, M;PURKINS, L;DAY, KC
在豚鼠中研究了母体饮食限制对四种脂肪组织库随后发育的影响。从自由采食（AL）的妊娠母猪中取出的胎仔和所产幼仔显示，在四个选定的贮库（肩胛间（IS）、腹膜后（RP）、腹股沟侧皮下（GS）和臂后皮下（BA）），脂肪垫质量和脂肪细胞质量随体重增加而增加。母体饮食限制（妊娠后半期50% AL口粮）的作用是显著降低幼仔出生时的体重。BA和GS脂肪垫的质量以及贮库中脂肪细胞的质量相应地减少。然而，IS和RP脂肪垫的脂肪贮库质量和脂肪细胞质量大于AL饲喂母猪所产体重相当的幼崽。在怀孕的后半期，饮食限制对“产热”脂肪组织库（IS和RP）产生了优先的“节约”效应，这表明“产热”脂肪组织比“储存脂肪组织”（BA和GS）更有可能在怀孕早期被“编程"。
The effect of maternal diet restriction on the subsequent development of four adipose tissue depots has been studied in the guinea-pig. Fetuses taken from, and pups born to, pregnant sows fed ad libitum (AL) displayed an increase in fat pad mass and in fat cell mass with increasing body mass at the four selected depots (interscapular (IS), retroperitoneal (RP), groin side subcutaneous (GS) and behind arm subcutaneous (BA). The effect of maternal diet restriction (50% AL rations during the second half of pregnancy) was to significantly reduce the body masses at birth of the pups. The masses of the BA and GS fat pads and the mass of fat cells in the depots were reduced accordingly. However, the fat depot masses and fat cell masses of the IS and RP fat pads were larger than those of pups of comparable body mass born to AL fed sows. Diet restriction during the second half of pregnancy exerted preferential ''sparing'' effects on the ''thermogenic'' adipose tissue depots (IS and RP) suggesting the possibility that ''thermogenic'' adipose tissue is more likely to be ''programmed'' earlier in pregnancy than ''storage adipose tissue'' (BA and GS).