STRUCTURE AND FUNCTION OF RECEPTORS COUPLED TO G-PROTEINS
STRUCTURE AND FUNCTION OF RECEPTORS COUPLED TO G-PROTEINS
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DOI：
10.1016/0955-0674(94)90134-1
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发表时间：
1994-04-01
影响因子：
7.5
通讯作者：
BALDWIN, JM
中科院分区：
文献类型：
--
作者：
BALDWIN, JM
去年以视紫红质的低分辨率投影图的形式获得了与G蛋白偶联的受体的直接结构数据。现在已经确定了大量的受体序列，对这些序列的详细分析提供了关于受体的结构信息。从定点诱变实验的新结果可以检查结合从序列分析和视紫红质地图的结构信息。组成型活性突变受体的鉴定影响了我们对正常受体平衡的理解。
Direct structural data on receptors coupled to G proteins were obtained last year in the form of a low resolution projection map of rhodopsin. A large number of receptor sequences have now been determined and detailed analysis of these has provided structural information about the receptors. New results from site-directed mutagenesis experiments can be examined in conjunction with the structural information from sequence analysis and the rhodopsin map. The identification of constitutively active mutated receptors has influenced our understanding of normal receptor equilibria.