Studies on the linkage between spin equilibria and protein structure in carp ferric hemoglobin.
Studies on the linkage between spin equilibria and protein structure in carp ferric hemoglobin.
复制标题
鲤鱼铁血红蛋白自旋平衡与蛋白质结构关系的研究。
DOI：
10.1111/j.1432-1033.1987.tb13454.x
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Cerdonio,M
中科院分区：
文献类型：
--
作者：
Noble,RW;DeYoung,A;Vitale,S;Morante,S;Cerdonio,M
The effects of protein conformation on the spin‐state equilibria of several derivatives of carp hemoglobin have been examined. This has been done by measuring the pH dependence of the paramagnetic susceptibilities of these derivatives in the presence and absence of inositol hexakisphosphate,P6‐inositol. In all cases the addition ofP6‐inositol at low pH and the lowering of the pH in the presence ofP6‐inositol shift the spin‐state equilibrium in favor of the high‐spin electronic configuration. TheP6‐inositol and pH dependence of these magnetic properties parallels the pH andP6‐inositol dependence of the conformational state of the hemoglobin as determined in earlier studies and further supports a thermodynamic linkage between the electronic state of the iron atoms and the quaternary structure of the hemoglobin molecule.
