Contact tracing in pulmonary and non-pulmonary tuberculosis
Contact tracing in pulmonary and non-pulmonary tuberculosis
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DOI：
10.1093/qjmed/hcs045
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发表时间：
2012-08-01
影响因子：
13.3
通讯作者：
Hill, A. T.
中科院分区：
文献类型：
--
作者：
Mandal, P.;Craxton, R.;Hill, A. T.
目的：我们的研究的目的是确定肺和非肺tuberculosis（TB）的接触者追踪的有效性。方法：作者研究了接触者追踪在苏格兰东南部，爱丁堡结核病诊所，英国，3年。肺结核和非肺结核的新指标病例是通过审查结核病护士的记录确定的。所有非肺部病例均排除肺部受累。根据国家结核病指南诊断活动性结核病。根据病史、结核菌素皮试和干扰素γ释放试验诊断潜伏性结核病。结果：肺结核筛查阳性率为43.1%，非肺结核筛查阳性率为26.1%。其中，78.8%是家庭接触者，21.2%是偶然的contacts.Conclusion：在低流行率结核病国家的接触者追踪，肺结核和非肺结核，是一个必不可少的干预措施，以确定和减少感染的患者，将进展到活动性疾病的数量。这是有效控制结核病的关键。
Aim: The aim of our study was to determine the effectiveness of contact tracing for both pulmonary and non-pulmonary tuberculosis (TB).Methods: The authors studied contact tracing in South East of Scotland, Edinburgh TB Clinic, UK, for 3 years. New index cases of both pulmonary and non-pulmonary TB were identified from reviewing TB nurses records. Pulmonary involvement was excluded from all non-pulmonary cases. Active TB was diagnosed as per the national TB guidelines. Latent TB was diagnosed based on history, tuberculin skin test and interferon gamma release assay. TB contacts were identified from reviewing TB nurses notes on index TB patients.A positive screening episode was defined as identification of either active or latent TB in a contact following relevant investigations.Results: Total number of positive screening episodes for pulmonary TB was 43.1% and non-pulmonary TB was 26.1%. Of these, 78.8% were household contacts and 21.2% were casual contacts.Conclusion: Contact tracing in low-prevalence TB countries, for both pulmonary and non-pulmonary TB, is an essential intervention to identify and reduce the number of infected patients that will progress to active disease. This is the key for effective TB control.