Purinergic dysfunction in mania: an integrative model
Purinergic dysfunction in mania: an integrative model
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DOI：
10.1054/mehy.2001.1543
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发表时间：
2002-04-01
影响因子：
4.7
通讯作者：
Kapczinski, F
中科院分区：
文献类型：
--
作者：
Machado-Vieira, R;Lara, DR;Kapczinski, F
嘌呤能系统包括抗惊厥和抗点燃神经调节剂腺苷和神经递质ATP，调节第二信使系统、神经递质、能量代谢和不同的行为，如睡眠、运动活动、认知、记忆、攻击行为和社会互动。与此同时，躁狂症的特点是类似的行为变化和分子基础，以解释在躁狂发作期间观察到的病理激活也与第二信使系统功能障碍和点燃有关。这一假说提出了一个神经元通讯的综合模型，将腺苷能活性降低（主要是在Al受体）与神经递质变化的复杂网络联系起来;与躁狂行为相关的通路。(C)2002爱思唯尔科技有限公司版权所有。
The purinergic system, which includes the anticonvulsant and antikindling neuromodulator adenosine and the neurotransmitter ATP, modulates second messenger systems, neurotransmitters, energy metabolism and different behaviors, such as sleep, motor activity, cognition, memory, aggressive behavior and social interaction. At the same time, mania is characterized by similar behavioral changes and a molecular basis to explain the pathological activation observed during manic episodes has been also associated with second messenger systems dysfunction and kindling. This hypothesis put forward an integrative model of neuronal communication, associating a reduced adenosinergic activity, mostly at Al receptors, with the complex network of changes on neurotransmitters; pathways related to manic behavior. (C) 2002 Elsevier Science Ltd. All rights reserved.