Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition
Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition
复制标题
阿魏酸通过调节上皮间质转化发挥抗肿瘤活性并抑制乳腺癌细胞的转移
DOI：
10.3892/or.2016.4804
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发表时间：
2016-07-01
期刊：
影响因子：
4.2
通讯作者：
Li, Hongyuan
中科院分区：
文献类型：
--
作者：
Zhang, Xiang;Lin, Dan;Li, Hongyuan
乳腺癌中经常发生的转移是死亡的主要原因，因此，迫切需要新的治疗策略。从多年生草本植物阿魏（Ferula foetida）中分离出的阿魏酸已显示出对各种类型的癌症如结肠癌和肺癌以及中枢神经系统肿瘤的抑制活性。然而，其在抑制乳腺癌转移中的潜在作用尚未完全了解。在本研究中，我们评估了阿魏酸在乳腺癌细胞系的体外和体内模型中的抗肿瘤活性。我们首先表明，阿魏酸处理导致乳腺癌细胞系MDA-MB-231的活力降低，细胞凋亡增加和转移潜能抑制。此外，已证明阿魏酸的抗肿瘤活性及其在抑制转移中的作用是通过逆转上皮-间充质转化（EMT）来调节的。与我们的体外研究结果一致，阿魏酸的抗肿瘤潜力也在MDA-MB-231异种移植小鼠模型中得到验证，其中观察到肿瘤体积、重量显著降低和细胞凋亡增加。综上所述，这些结果表明，阿魏酸可用作抗乳腺癌的有效治疗剂。
Metastasis, which frequently occurs in breast cancer, is the major cause of mortality; therefore, new treatment strategies are urgently needed. Ferulic acid, isolated from Ferula foetida, a perennial herb, has shown antineoplastic activity in various types of cancers, such as colon and lung cancer, and central nervous system tumors. However, its potential role in suppressing breast cancer metastasis has not been fully understood. In the present study, we evaluated the antitumor activity of ferulic acid in breast cancer cell line-based in vitro and in vivo models. We first showed that ferulic acid treatment resulted in decreased viability, increased apoptosis and suppression of metastatic potential in breast cancer cell line MDA-MB-231. Furthermore, it was demonstrated that the antitumor activity of ferulic acid and its role in suppressing metastasis were regulated by the reversal of epithelial-mesenchymal transition (EMT). Consistent with our findings in vitro, the antitumor potential of ferulic acid was also verified in an MDA-MB-231 xenograft mouse model where significantly decreased tumor volume, weight and increased apoptosis were observed. Taken together, these results indicate that ferulic acid may be used as an effective therapeutic agent against breast cancer.