Changing hypothalamopituitary function: its role in aging of the female reproductive system.
Changing hypothalamopituitary function: its role in aging of the female reproductive system.
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改变下丘脑垂体功能：其在女性生殖系统衰老中的作用。
DOI：
10.1159/000181084
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Larson,GH
中科院分区：
文献类型：
--
作者：
Wise,PM;Weiland,NG;Scarbrough,K;Sortino,MA;Cohen,IR;Larson,GH
在许多哺乳动物物种中，雌性生殖功能的变化发生在生命周期的相对早期。因此，这个生理系统是一个很好的模型系统，其中研究年龄对特定内分泌关系的影响，因为变化发生在与衰老后期相关的多种病理发生之前。来自几个实验室的数据表明，下丘脑、垂体和卵巢功能的变化可能导致女性生育力与年龄相关的恶化。我们将把注意力集中在下丘脑变化在最终导致非周期性和不孕症的级联事件中的作用上。数据表明，在昼夜节律性的儿茶酚胺能神经递质及其受体的变化发生在中年。这些变化可能调节GnRH的释放模式，因为LH分泌的脉动模式的改变在这个年龄也变得可检测。下丘脑和垂体功能的一些年龄相关变化不是不可逆的或绝对确定的。相反，似乎卵巢类固醇环境调节下丘脑垂体功能的几个方面的衰老速度。总之，下丘脑和垂体功能的变化似乎有助于女性生殖系统的老化。
Changes in female reproductive function occur relatively early during the life span in many mammalian species. Therefore, this physiological system is an excellent model system in which to study the effects of age on specific endocrine relationships since changes occur prior to the occurrence of multiple pathologies associated with later stages of aging. Data from several laboratories suggest that changes in hypothalamic, pituitary and ovarian function may contribute to age-related deterioration of fertility in females. We will focus our attention on the role of hypothalamic changes in the cascade of events that eventually lead to acyclicity and infertility. Data suggest that changes in the diurnal rhythmicity of catecholaminergic neurotransmitters and their receptors occur during middle age. These changes may regulate the pattern of release of GnRH since alterations in the pulsatile pattern of LH secretion also become detectable at this age. Some age-related changes in hypothalamic and pituitary function are not irreversible or absolutely determined. Instead it appears that the ovarian steroidal milieu modulates the rate of aging of several aspects of hypothalamohypophysial function. In summary, changes in hypothalamic and pituitary function appear to contribute to the aging of the female reproductive system.