The Frequency of Peripheral Blood CD4+ CD25high FoxP3+ and CD4+ CD25− FoxP3+ Regulatory T Cells in Normal Pregnancy and Pre‐Eclampsia
The Frequency of Peripheral Blood CD4+ CD25high FoxP3+ and CD4+ CD25− FoxP3+ Regulatory T Cells in Normal Pregnancy and Pre‐Eclampsia
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DOI：
10.1111/j.1600-0897.2012.01145.x
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发表时间：
2012-08
影响因子：
3.6
通讯作者：
G. Toldi;S. Saito;T. Shima;A. Halmos;Z. Veresh;B. Vásárhelyi;J. Rigó;A. Molvarec
中科院分区：
文献类型：
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作者：
G. Toldi;S. Saito;T. Shima;A. Halmos;Z. Veresh;B. Vásárhelyi;J. Rigó;A. Molvarec
调节性T细胞（Treg）在妊娠特异性免疫耐受的发展中起着重要作用。我们的目的是确定最近描述的Treg亚群的外周频率，CD 4 + CD 25 − FoxP 3 + Treg亚群，以及与正常妊娠（NP）和先兆子痫（PE）女性相比，非妊娠（non-P）女性中常规CD 4 + CD 25 high FoxP 3 + Treg的相关性。我们还检测了常规Treg细胞中活化的CD 4 + CD 25 high FoxP 3 high Treg亚群的比例。
Regulatory T cells (Tregs) play an important role in the development of pregnancy‐specific immune tolerance. We aimed to determine the peripheral frequency of a recently described Treg subpopulation, the CD4+ CD25− FoxP3+ Treg subset, and its correlation with the conventional CD4+ CD25high FoxP3+ Tregs in normal pregnancy (NP) and pre‐eclampsia (PE) compared to non‐pregnant (non‐P) women. We also examined the proportion of the activated CD4+ CD25high FoxP3high Treg subset within conventional Treg cells.