RISK OF EARLY DEATH IN EXTREMELY OVERWEIGHT YOUNG MEN
RISK OF EARLY DEATH IN EXTREMELY OVERWEIGHT YOUNG MEN
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DOI：
10.1136/bmj.287.6395.795
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发表时间：
1983-01-01
影响因子：
105.7
通讯作者：
CHRISTENSEN, U
中科院分区：
文献类型：
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作者：
SONNEHOLM, S;SORENSEN, TIA;CHRISTENSEN, U
研究人员对1239名极度超重的男性进行了研究，研究对象是青少年时期明显肥胖对后期死亡率的影响，超重的定义是体重/身高比为2。在1943-1977年期间，在哥本哈根[丹麦]地区331,919名应服兵役的男子中，31公斤/平方米。从剩余的研究人群中随机抽取2948人作为对照组。所有的男性都被跟踪到1980年11月，到那时，极度超重的受试者中有33人死亡，而对照组中有89人死亡。由此得出，对照组的死亡率（观察到的死亡人数与预期死亡人数之比）为1.14(95%置信限0.91-1.40)，而肥胖受试者的死亡率明显更高，为1.73（95%置信限1.20-2.41）。根据生存时间分布估计，在37年的观察中，相对风险相当稳定，约为1.6。在回归分析中考虑年龄和入组年份并没有改变相对死亡风险。肥胖组30岁前自然死亡比例显著高于对照组，30岁后无明显差异。青少年明显肥胖是一种健康危害，尤其表现在成年早期自然原因造成的死亡率明显增加。
The effect of pronounced obesity in youth on later mortality was studied in 1239 men with extreme overweight, defined as a weight/height2 .gtoreq. 31 kg/m2, in the population of 331,919 men liable for military service in the Copenhagen [Denmark] area during the period 1943-1977. A random sample of 2948 drawn from the remaining study population served as a control group. All men were followed up until November 1980, by which time 33 deaths had occurred among the extremely overweight subjects compared with 89 in the control group. This gave a mortality ratio (observed to expected number of deaths) of 1.14 (95% confidence limit 0.91-1.40) for controls with a significantly greater mortality of 1.73 (95% confidence limit 1.20-2.41) for obese subjects. The relative risk, estimated from the survival time distributions, was fairly constant around 1.6 throughout the 37 yr of observation. Taking into account age at and year of entry in a regression analysis did not change the relative mortality risk. The proportion of natural death was significantly higher in the obese group than in the control group until the age of 30 but not thereafter. Pronounced obesity in youth is a health hazard, manifesting itself particularly in a distinct increase in mortality from natural causes in early adulthood.