Associations Between Sleep Duration, Daytime Nap Duration, and Osteoporosis Vary by Sex, Menopause, and Sleep Quality
Associations Between Sleep Duration, Daytime Nap Duration, and Osteoporosis Vary by Sex, Menopause, and Sleep Quality
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睡眠时间、白天小睡时间和骨质疏松症之间的关联因性别、更年期和睡眠质量而异
DOI：
10.1210/jc.2013-3629
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发表时间：
2014-08-01
影响因子：
5.8
通讯作者：
Ning, Guang
中科院分区：
文献类型：
--
作者：
Chen, Gang;Chen, Ling;Ning, Guang
背景：睡眠、白天午睡时间和骨质疏松症之间的关系仍然不确定，甚至对性别、更年期和睡眠质量对它们的影响所知甚少。目的：该研究的目的是测试睡眠、白天午睡时间和骨质疏松症之间的关系，以及它们是否因性别、更年期和睡眠质量而变化。设计、环境和患者：这项横断面研究基于中国的两个社区。共有8688名年龄在40岁或以上的参与者（3950名男性和4738名女性）参加了这项研究。主要结局指标：记录自我报告的睡眠时间、白天午睡时间、睡眠质量和跟骨骨密度。结果：以8 ~ 9 h/d的睡眠时间和0 min/d的午睡时间为参考值。绝经后妇女睡眠时间为7-8 h/d、9-10 h/d和10 h/d及以上的骨质疏松风险（优势比和95%可信区间）分别为1.531（1.106,2.121）、1.360（1.035,1.787）和1.569 (1.146,2.149)(P < 0.05)，白天睡眠时间为30-60 min/d和超过60 min/d的骨质疏松风险分别为1.553（1.212-1.989）和1.645 (1.250-2.165)（P < 0.05）。然而，无论睡眠时间或白天午睡时间长短，在男性或绝经前女性中并未观察到显著差异。至于睡眠质量，在睡眠良好的绝经后女性中，积极的结果最为显著。结论：7-8小时/天、9-10小时/天、10小时/天或更长时间的睡眠，以及较长的白天午睡时间，往往会增加患骨质疏松症的风险，这种趋势在报告睡眠质量良好的绝经后妇女中最为明显。
Context: Associations between sleep, daytime nap duration, and osteoporosis remain uncertain, and far less is even known about the influence of sex, menopause, and sleep quality on them.Objective: The objective of the study was to test the associations between sleep, daytime nap duration, and osteoporosis and whether they vary by sex, menopause, and sleep quality.Design, Setting, and Patients: This cross-sectional study was based on two communities in China. A total of 8688 participants (3950 males and 4738 females) aged 40 years or older were enrolled in the study.Main Outcomes Measures: Self-reported sleep duration, daytime nap duration, sleep quality, and calcaneus bone mineral density were recorded.Results: Sleep duration of 8-9 h/d and nap duration of 0 min/d were regarded as reference values. In postmenopausal women, risks (odds ratio and 95% confidence interval) of osteoporosis for sleep durations of 7-8 h/d, 9-10 h/d, and 10 h/d or longer were 1.531 (1.106, 2.121), 1.360 (1.035, 1.787), and 1.569 (1.146, 2.149), respectively (P < .05), and risks of osteoporosis for daytime nap durations of 30-60 min/d and longer than 60 min/d were 1.553 (1.212-1.989) and 1.645 (1.250-2.165), respectively (P < .05). However, a significant difference was not consistently observed in men or premenopausal women, regardless of sleep or daytime nap duration. As for sleep quality, positive results were seen most remarkably in postmenopausal females with good sleep.Conclusions: Sleep durations of 7-8 h/d, 9-10 h/d, and 10 h/d or longer, as well as longer daytime napping times, tend to present higher risks of having osteoporosis, and this tendency is most obvious in postmenopausal women reporting good-quality sleep.