Manipulation of cellular syntheses and the nature of viruses: The virocell concept
Manipulation of cellular syntheses and the nature of viruses: The virocell concept
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DOI：
10.1016/j.crci.2010.06.007
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发表时间：
2011-04-01
影响因子：
1.6
通讯作者：
Forterre, Patrick
中科院分区：
文献类型：
--
作者：
Forterre, Patrick
最近，几位作者提出，病毒是古老的有机体，应该在描述生命历史的进化场景中引入。然而，这些观点受到了支持病毒是细胞活动副产品的传统观点的作者的强烈反对。长期以来，病毒确实被混淆为病毒粒子，即没有新陈代谢活动的惰性粒子，将它们排除在生命领域之外。我在这里介绍病毒细胞的概念，以强调病毒生命周期的细胞内阶段。这一概念假设病毒是细胞--从而是活的--有机体，并突出了病毒创造新基因以操纵其细胞环境和创造新的生物机制的能力。这个概念有助于解释为什么病毒在生命史上扮演着重要的角色。它建议更系统地挖掘病毒世界，为合成生物学寻找新的工具。(C)2010年科学院。爱思唯尔·马森公司出版。版权所有。
Recently, several authors have suggested that viruses are ancient organisms that should be introduced in evolutionary scenarios describing the history of life. However, these views have been strongly disputed by authors who support the traditional view of viruses as byproducts of cellular activity. For a long time, viruses have been indeed confused with virions, inert particles without metabolic activity, excluding them from the realm of life. I introduce here the concept of virocell, to put emphasis on the intracellular phase of the virus life cycle. This concept posits that viruses are cellular - thus living - organisms, and highlight the capacity of viruses to create new genes to manipulate their cellular environment and to create novel biological mechanisms. This concept helps to explain why viruses have played a major role in the history of life. It suggests to mine more systematically the viral world to find new tools for synthetic biology. (C) 2010 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.