Erroneous diagnosis of small cell lung cancer based on small biopsies with far-reaching consequences: case report of a typical carcinoid tumor
Erroneous diagnosis of small cell lung cancer based on small biopsies with far-reaching consequences: case report of a typical carcinoid tumor
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DOI：
10.21037/jtd.2017.02.35
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发表时间：
2017-02-01
影响因子：
2.5
通讯作者：
Welter, Stefan
中科院分区：
文献类型：
--
作者：
Kyritsis, Ioannis;Krebs, Bettina;Welter, Stefan
虽然肺的神经内分泌肿瘤(Net)经常被讨论在一起，但类癌与高级别小细胞肺癌(SCLC)有很大的不同。小细胞肺癌是在大量吸烟的老年患者中发现的，而吸烟与类癌肿瘤没有很强的相关性。我们报告一位46岁从不吸烟的女性被误诊为小细胞肺癌的病例。根据最终的病理报告，患者对放化疗加预防性颅脑照射(PCI)无效；她患有典型的类癌(TC)肿瘤。我们的目的是证明，当临床特征不常见时，或当随访评估显示对系统治疗没有反应时，必须仔细检查基于细胞学或小活检标本的小细胞肺癌诊断。
Although neuroendocrine tumors (NETs) of the lung are frequently discussed together, carcinoids are very different from high-grade small cell lung carcinoma (SCLC). SCLC is found in heavy smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. We present the case of a 46-year-old never smoking woman who was misdiagnosed with SCLC. The patient was not responsive to radio-chemotherapy plus prophylactic cranial irradiation (PCI); she had a typical carcinoid (TC) tumor according to the final pathology report. We aim to demonstrate that diagnosis of SCLC based on cytology or small biopsy specimens must be scrutinized when the clinical constellation is unusual, or when the follow-up assessment shows no response to systemic treatment.