Link between vitamin D and airway remodeling.
Link between vitamin D and airway remodeling.
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DOI：
10.2147/jaa.s46944
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发表时间：
2014
影响因子：
3.2
通讯作者：
Hamzaoui A
中科院分区：
文献类型：
--
作者：
Berraies A;Hamzaoui K;Hamzaoui A
在过去的十年里，许多流行病学研究调查了维生素D缺乏和哮喘之间的联系。大多数研究表明，维生素D缺乏会增加患哮喘和过敏的风险。低水平的维生素D与哮喘的严重程度和控制失控以及反复加重有关。重塑是哮喘的早期事件，被描述为炎症和常驻的支气管细胞产生介质和生长因子的结果。结果，肺功能改变，一秒内用力呼气量减少，并加剧了呼吸道高反应性。上皮下纤维化和气道平滑肌细胞肥大是呼吸道结构改变的典型特征。在动物模型中，维生素D缺乏会加剧炎症和支气管异常。在严重的儿童哮喘中，维生素D水平低的患者可以观察到主要的重构。相反，维生素D在平滑肌细胞中的抗纤维化和抗增殖作用已经在几个实验中得到了描述。本文就维生素D与哮喘关系的研究现状作一综述，重点介绍维生素D对气道重塑的影响及其对哮喘的潜在治疗作用。
In the last decade, many epidemiologic studies have investigated the link between vitamin D deficiency and asthma. Most studies have shown that vitamin D deficiency increases the risk of asthma and allergies. Low levels of vitamin D have been associated with asthma severity and loss of control, together with recurrent exacerbations. Remodeling is an early event in asthma described as a consequence of production of mediators and growth factors by inflammatory and resident bronchial cells. Consequently, lung function is altered, with a decrease in forced expiratory volume in one second and exacerbated airway hyperresponsiveness. Subepithelial fibrosis and airway smooth muscle cell hypertrophy are typical features of structural changes in the airways. In animal models, vitamin D deficiency enhances inflammation and bronchial anomalies. In severe asthma of childhood, major remodeling is observed in patients with low vitamin D levels. Conversely, the antifibrotic and antiproliferative effects of vitamin D in smooth muscle cells have been described in several experiments. In this review, we briefly summarize the current knowledge regarding the relationship between vitamin D and asthma, and focus on its effect on airway remodeling and its potential therapeutic impact for asthma.